Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Polycystic kidney disease

26.01.2006


NIH and PKD Foundation launch HALT-PKD treatment trials



The National Institutes of Health (NIH) and the PKD Foundation have launched two treatment trials for autosomal dominant polycystic kidney disease (ADPKD). The common inherited disorder is characterized by cysts in the kidneys and other organs, high blood pressure, and aneurysms (bulges in blood vessels, which may burst) in the brain. Symptoms usually appear between the ages of 30 and 40 and include back and side pain and headaches. About half of ADPKD patients eventually develop kidney failure and require dialysis or a kidney transplant. The first Halt Progression of Polycystic Kidney Disease (HALT-PKD) patient enrolled last week at Emory University in Atlanta, one of seven recruitment sites (www.pkd.wustl.edu/pkd-tn).

"Decades of clinical and basic studies by NIH and others have delivered this exciting opportunity for translational research," says Catherine M. Meyers, M.D., a kidney specialist who directs HALT-PKD at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). "Naturally, we appreciate the PKD Foundation’s invaluable guidance and support."


PKD Foundation President and CEO Dan Larson applauded the start of the trials. "PKD families are eager to learn of any potential benefits," says Larson. "Their hope and the hope of the PKD Foundation is that this will be a step toward finding a cure for PKD and improving the care and treatment of those it affects."

Carefully controlling blood pressure and using ACE-inhibitors or ARBs significantly delays or prevents kidney disease and failure from diabetes and other causes by reducing protein in the urine and preventing damage to the small blood vessels in the kidneys. Earlier trials of these treatments in PKD were not definitive, possibly because a small number of patients were involved.

Over the next 2 years, HALT-PKD will recruit more than 1,000 people with ADPKD and treat them for up to 4 years at centers in Atlanta, Boston, Cleveland, Denver, Kansas City, Kansas, and Rochester, Minnesota. The two trials will compare standard therapy using an angiotensin-converting enzyme inhibitor (ACE-inhibitor) to intensive therapy using both an ACE-inhibitor and an angiotensin receptor blocker (ARB). Patients will receive a device for measuring blood pressure at home, clinic visits, lab tests, and study medications at no charge. They will also have their kidney function estimated using a standard blood test measurement called eGFR and other measures to track progression of kidney disease.

HALT-PKD Study A, for people 15 to 49 years of age with early disease (eGFR >60), will also compare standard (120-130/70-80 mm Hg) and low (95-110/60-75 mm Hg) blood pressure targets and measure changes in cyst and kidney size using a Magnetic Resonance Imaging method developed by NIDDK’s Consortium for Radiologic Imaging Studies of PKD. Study B, for people 18 to 64 and more advanced disease (eGFR 30-60), will track the time it takes eGFR to drop by 50 percent, the need for kidney failure treatment, and patient deaths.

PKD affects an estimated 500,000 people, about 90 percent of whom have ADPKD. In 2003, 23,000 people with cystic kidney disease (mostly PKD) received dialysis or a kidney transplant, making it this country’s fourth leading cause of kidney failure. While genetic testing for ADPKD can help determine whether a family member can safely donate a kidney, testing can’t predict onset of symptoms or severity of the disease, which also increases the risk of heart attacks, strokes and early death compared to the general population.

Mary Harris | EurekAlert!
Further information:
http://www.nih.gov
http://www.pkd.wustl.edu/pkd-tn

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>