People who have a specific genetic variant of the PTPN22 gene and test positive for antibodies against cyclic citrullinated peptide are much more at risk of developing rheumatoid arthritis than people who only have one of these markers.
A study published today in the journal Arthritis Research & Therapy reveals that a group of people who have a specific genetic variant, or polymorphism, of PTPN22, a gene that encodes a tyrosine phosphatase protein, and tested positive for anti-cyclic citrullinated peptide (CCP) antibodies, all developed rheumatoid arthritis (RA) in the following two and a half years. Both the polymorphism and anti-CCP antibodies have previously been shown to be associated with RA, but in combination they give a much higher risk of developing the disease than separately. This combination gives a much higher relative risk than the combination of anti-CCP antibodies and the previously well-known genetic factor, namely HLA DR4 antigens.
Martin Johansson and colleagues from the University Hospital in Umea, Sweden studied a population of 92 patients diagnosed with RA for whom a blood sample was available, which had been taken on average about two and a half years before the onset of the disease. They were matched with controls - blood donors from the same group who didnt develop arthritis - for age, sex, and rural or urban residence.
Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
27.03.2017 | Earth Sciences
27.03.2017 | Life Sciences
27.03.2017 | Life Sciences