A decreased ability to repair chromosomal damage caused by exposure to ultraviolet B (UV-B) radiation in test tubes may be associated with an increased risk of the common skin cancers basal cell carcinoma and squamous cell carcinoma, but not of melanoma, according to a study in the December 21 issue of the Journal of the National Cancer Institute.
Exposure to UV radiation from sunlight is a risk factor for the two most common skin cancers, basal cell carcinoma and squamous cell carcinoma, and for the less common and potentially lethal skin cancer cutaneous malignant melanoma. UV-B radiation can cause strands of DNA to break in sun-exposed skin or skin cells. People with a condition called xeroderma pigmentosum are at a very high risk of sunlight-induced skin cancer because their cells are unable to repair these kinds of DNA and chromosomal damage. However, scientists did not know if the frequency of UV-B induced chromatid breaks, an indirect estimate of DNA repair capacity, is a risk factor for skin cancer in the general population.
Li-E Wang, M.D., and Qingyi Wei, M.D., Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues set out to answer this question by studying 469 patients with both melanoma or nonmelanoma skin cancers and 329 cancer-free patients. They took blood samples from all of the patients and then measured the number of chromatid breaks in the patients cells 24 hours after the blood samples were exposed to UV-B radiation.
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
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16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences