A decreased ability to repair chromosomal damage caused by exposure to ultraviolet B (UV-B) radiation in test tubes may be associated with an increased risk of the common skin cancers basal cell carcinoma and squamous cell carcinoma, but not of melanoma, according to a study in the December 21 issue of the Journal of the National Cancer Institute.
Exposure to UV radiation from sunlight is a risk factor for the two most common skin cancers, basal cell carcinoma and squamous cell carcinoma, and for the less common and potentially lethal skin cancer cutaneous malignant melanoma. UV-B radiation can cause strands of DNA to break in sun-exposed skin or skin cells. People with a condition called xeroderma pigmentosum are at a very high risk of sunlight-induced skin cancer because their cells are unable to repair these kinds of DNA and chromosomal damage. However, scientists did not know if the frequency of UV-B induced chromatid breaks, an indirect estimate of DNA repair capacity, is a risk factor for skin cancer in the general population.
Li-E Wang, M.D., and Qingyi Wei, M.D., Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues set out to answer this question by studying 469 patients with both melanoma or nonmelanoma skin cancers and 329 cancer-free patients. They took blood samples from all of the patients and then measured the number of chromatid breaks in the patients cells 24 hours after the blood samples were exposed to UV-B radiation.
The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo
Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine
Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
23.10.2017 | Event News
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