Pairing the targeted therapy Herceptin with chemotherapy in patients with early stage breast cancer significantly increases disease-free survival time in women who test positive for a genetic mutation that results in a particularly aggressive form of the disease, according to large, international study.
The study also tested Herceptin with a chemotherapy combination that eliminated Adriamycin, an anthracycline commonly used to treat breast cancer but a drug that, when used with Herceptin, can result in heart damage. That regimen also significantly improves survival.
Conducted by the Breast Cancer International Research Group (BCIRG), this study is the fourth large clinical trial to show that Herceptin plus chemotherapy significantly reduces risk of disease recurrence in early breast cancer. Results were presented Thursday at the San Antonio Breast Cancer Symposium by Dr. Dennis Slamon, co-chairman of BCIRG, director of Clinical/Translational Research at UCLAs Jonsson Cancer Center and the scientist whose laboratory and clinical research laid the groundwork for the development of Herceptin.
Kim Irwin | EurekAlert!
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