The bronchial tubes of a patient with severe asthma can become scarred due to repeated episodes of allergic inflammation in the airways. The scarring results in blocked airways, excessive production of mucus, and shortness of breath.
Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that when a single gene – IKK beta – is selectively inactivated in the membrane-lining cells of the bronchial tubes of mice that later inhale allergens, such scarring, mucus production and airway inflammation is significantly reduced.
David H. Broide, M.B.,Ch.B., Professor in UCSD’s Department of Medicine, and Michael Karin, Ph.D., Professor in UCSD’s Department of Pharmacology and the Laboratory of Gene Regulation and Signal Transduction, will publish their findings in the December 6 issue of the Proceedings of the National Academy of Sciences.
Debra Kain | EurekAlert!
Further information:
http://www.ucsd.edu
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