Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

ADHD medication might also treat hyperactivity symptoms in autism

22.11.2005


Methylphenidate, a medication used to treat attention-deficit hyperactivity disorder (ADHD), may be effective in treating hyperactivity symptoms in children with autism and related pervasive developmental disorders, researchers report in the November Archives of General Psychiatry.



The study was conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, a National Institute of Mental Health funded multi-site consortium dedicated to the development and testing of treatments for children with pervasive developmental disorders such as autism. The Yale team is directed by Lawrence Scahill, associate professor of nursing and child psychiatry at Yale.

"This study shows that methylphenidate is an effective medication for children with pervasive developmental disorder (PDD) accompanied by increased hyperactivity," said Scahill. "However, the percentage of children showing a positive response and the magnitude of benefit is lower than what we have come to expect in ADHD uncomplicated by PDD."


"Although the adverse effects that we observed in this study are similar to what we see in typically developing children with ADHD, these adverse effects occurred at a much higher frequency in our study subjects, " Scahill added.

RUPP investigators conducted a randomized, placebo-controlled trial to determine whether methylphenidate would be effective in reducing hyperactivity in children with PDD. The trial included a one-week test phase to ensure that subjects could tolerate three different dose levels of the medication, followed by a four-week (crossover) phase in which children were given one of three doses of methylphenidate or placebo to assess effectiveness. Parents, teachers and investigators, who rated the child’s behavior, were blind to the child’s drug dose. Children showing a positive response to any dose during the crossover phase were treated for an additional eight-week period to ensure the gains were stable.

The study evaluated 72 children between the ages of five and 14. Of the 58 participants who completed the crossover phase, 35 responded best to an active dose of methylphenidate and the drug was consistently more effective than placebo on measures of inattention, hyperactivity and impulsivity rated by parents and teachers.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Health and Medicine:

nachricht Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>