Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Common anti-seizure drug could be effective for lupus patients

17.11.2005


A common anti-seizure drug may be effective against certain conditions associated with lupus, according to animal research at Wake Forest University School of Medicine.



The drug, valproic acid (Depakote), prevents skin disease and reduces the severity of kidney disease in a mouse model of lupus, said Nilamadhab Mishra, M.D., a rheumatologist at Wake Forest University Baptist Medical Center.

"Valproic acid may be a potential cost-effective disease-modifying agent in lupus," Mishra reported today (Nov. 16) at the American College of Rheumatology meeting in San Diego.


And because the drug has been on the market since 1983, Mishra said that clinical trials to use valproic acid for lupus could begin as early as next year.

"We already know the side effects," he said. That means that researchers can skip over the safety studies and move quickly to clinical trials to test its efficacy. While physicians could prescribe valproic acid "off-label" to lupus patients, "it is better to have a clinical trial to prove that it does help in lupus," Mishra said.

Systemic lupus affects more than 1 million Americans, mostly women. About half of human patients with systemic lupus have kidney problems, but achy joints, skin lesions, frequent fever, arthritis and prolonged or extreme fatigue are far more common.

Mishra’s team tested valproic acid in a type of mouse that develops lupus that is similar to the lupus that occurs in people. None of the mice in the treatment group developed skin disease whereas all mice in the placebo group developed the disease, Mishra said. The results were similar for kidney and diseases of the spleen.

For instance, the spleen ordinarily enlarges in lupus. The size of the spleen in the treatment group was nearly one-third less than the size in the control group.

The study, which was paid for by a $250,000 grant from the Alliance for Lupus Research, was just one of several that Mishra presented at the national meeting,

In a second study, he showed that mithramycin, an antibiotic usually used against tumors, also reduces kidney disease in experimental mice with lupus.

Excess protein in the urine – proteinuria – is a symptom of kidney disease, Mishra said. In this study of mice born with lupus, only 33 percent of the mice getting mithrmycin had excess protein in the urine at 16 weeks, compared to 50 percent of the mice that were not treated. By 19 weeks, the gap had widened, with just 22.2 percent of the mithramycin group having excess protein, compared to 60 percent of the untreated group.

Other kidney function measures also showed a wide difference between the mithramycin group and the control mice. Renal vasculitis – inflammation of the tiny blood vessels in the kidney that can lead to kidney failure – occurred in 90 percent of the untreated mice, compared to 30 percent of the mithramycin group.

Mishra said that mithramycin might have a beneficial effect in people with lupus. "Further studies are warranted," he said.

At the same meeting, Mishra also described additional results from his ongoing research using a drug called TSA (Trichostatin A) on lupus. He described testing TSA on a second variety of mice that develop an autoimmune disorder similar to human systemic lupus.

In 2003, he had reported that in the same mouse model he used in the valproic acid and mithramycin studies, TSA led to a significant reduction in excess protein in the urine, inflammation of the kidneys, and spleen weight.

The new study, done in New Zealand Black and New Zealand White mice – which also develop an autoimmune disorder similar to lupus – had similar results.

Lupus is known as an autoimmune disorder because the body’s own immune system turns on the rest of the body and attacks tissues and organs including the joints, kidneys, heart, lungs, brain and blood.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>