Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Why children of parents with type 2 diabetes are at risk themselves

11.11.2005


The role of mitochondrial dysfunction in the pathogenesis of insulin resistance is a widely debated topic. It has been shown that young, lean, insulin-resistant offspring of parents with type 2 diabetes have reduced mitochondrial function. But the precise role of this decreased function in relation to insulin resistance and type 2 diabetes was not clear.



In a paper appearing online on November 10 in advance of print publication of the December issue of the Journal of Clinical Investigation, Gerald Shulman and colleagues from Yale University take muscle biopsies from these offspring and show that they have reduced mitochondrial content as assessed by electron microscopy. The subjects also have lower insulin-stimulated muscle glucose uptake and increased lipid content in muscle cells. However in contrast to two recent studies, the authors did not find any alterations in PGC-1a or PGC-1b or other downstream regulators of mitochondrial gene expression.

These results provide new insights into the earliest defects that may be responsible for the pathogenesis of type 2 diabetes. Moreover, reduced mitochondrial content could result in reduced mitochondrial function, which predisposes the offspring of type, 2 diabetic parents to muscle cell lipid accumulation, which then leads to defective insulin signaling and action.


TITLE: Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of Type 2 diabetic parents.

AUTHOR CONTACT:
Gerald Shulman
Yale Medical School, New Haven, CT USA
Phone: 203-737-1115
Fax: 203-737-4059
E-mail: gerald.shulman@yale.edu

Stacie Bloom | EurekAlert!
Further information:
http://www.the-jci.org

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>