Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nerve-Stimulation Therapy for Patients with Treatment-Resistant Depression Now Available in New York

07.11.2005


Vagus Nerve Stimulation (VNS) Therapy Is the Only Implantable Device Specifically Indicated for Long-term Treatment of TRD



NewYork-Presbyterian Hospital/Columbia University Medical Center is the first in the greater New York City-area to offer Vagus Nerve Stimulation (VNS) Therapy as a long-term treatment specifically approved by the FDA for treatment-resistant depression (TRD).

VNS Therapy is approved as a long-term adjunctive (add-on) treatment for patients 18 years of age and older who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments. VNS Therapy was approved for the treatment of drug-resistant epilepsy in 1997, and is now the first treatment specifically studied and approved for TRD.


Major depressive disorder is one of the most prevalent and serious illnesses in the U.S., affecting nearly 19 million Americans every year. Of those, one fifth, or approximately four million people, do not respond to multiple antidepressant treatments. For these people, psychotherapy, antidepressant medications, and even sometimes electroconvulsive therapy do not work, or only work for a short while and stop working over time. VNS Therapy is a newly approved treatment option for these people.

“Patients with treatment-resistant depression need safe and effective therapeutic options. The availability of an FDA-approved treatment for the long-term management of depression is an important development for the disturbingly large number of people with depression who have not responded to other approved treatment options,” says Dr. Sarah H. Lisanby, director of the Columbia Brain Stimulation Service at NewYork-Presbyterian/Columbia University Medical Center and associate professor of clinical psychiatry at Columbia University College of Physicians and Surgeons. She is also director of the Brain Stimulation and Neuromodulation Division, director of the Brain Behavior Clinic, and research scientist in the Department of Neuroscience at the New York State Psychiatric Institute.

“Open studies suggest that the benefits from VNS were sustained over time, and that VNS was very tolerable with few side effects,” continues Dr. Lisanby.

Early clinical research of VNS Therapy for TRD was conducted at study sites, including NewYork-Presbyterian/Columbia, beginning in 2001. Recent studies have found that half of patients with an average of 25 years of major depressive disorder and multiple treatment trials realized some clinical benefit; one-third of patients had at least a 50 percent improvement in their depression; and one out of six was depression-free after treatment with VNS Therapy. Patients also reported significant improvements in quality-of-life areas, such as vitality, mental health, emotional well-being, and social functioning.

“VNS Therapy is delivered from a small pacemaker-like device implanted in the chest area that sends mild pulses to the brain via the vagus nerve in the neck. A thin, insulated wire, attached to the generator, runs under the skin to the left vagus nerve,” says Dr. Guy M. McKhann II, Florence Irving Assistant Professor of Neurological Surgery at Columbia University College of Physicians and Surgeons and assistant attending neurosurgeon at NewYork-Presbyterian/Columbia University Medical Center. The vagus nerve, one of the 12 cranial nerves, serves as the body’s “information highway” connecting the brain to many major organs. Several studies have shown that VNS Therapy may modulate neurotransmitters such as serotonin and norepinephrine thought to be involved in mood regulation.

Cyberonics, Inc., of Houston, manufactures the VNS Therapy System™.

For more information, interested patients may call (212) 543-5558 or email depression@columbia.edu.

Craig LeMoult | EurekAlert!
Further information:
http://www.columbia.edu

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>