Does a combination of radiation therapy and the inhibition of integrins (key molecules in angiogenesis) improve the chance of cure in cancer?
An increasing number of cancer patients are cured today by radiation therapy – alone or in combination with surgery or chemotherapy. At the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), scientists of the Clinical Cooperation Unit “Radiation Oncology” headed by Professor Dr. Dr. Peter Huber are identifying ways to further enhance the effectiveness of this type of treatment. The research team is targeting a weak point of the tumor: the formation of new blood vessels, or angiogenesis.
Once a tumor has reached pinhead size, it needs a supply of blood by blood vessels. If this supply is cut off, tumor growth comes to a halt. To suppress the formation of new blood vessels, integrins are a suitable target. This protein family comprises about 20 members that are involved in cell-cell interaction and regulate contacts with the surrounding protein matrix. Integrins play a key role in the formation of new blood vessels.
Julia Rautenstrauch | alfa
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