Large study pinpoints genetic and environmental factors
A case-control study of more than 2000 people has identified a number of factors that may induce primary biliary cirrhosis (PBC) in genetically susceptible individuals. These include a history of urinary tract infections, hormone replacement therapy, tobacco use, and nail polish use. The study is published in the November 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.
PBC is a rare autoimmune disease which leads to liver failure. The cause of the disease is unknown. It is more prominent in women, and researchers have found instances of familial clustering, as well as association with urinary tract infections, tobacco smoking, and estrogen use, though some of the existing studies have offered conflicting evidence.
David Greenberg | EurekAlert!
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