The active metabolite of vitamin D, calcitriol, and other vitamin D analogs are promising chemopreventive agents that may prevent prostate cancer, according to a study presented today at the American Association for Cancer Researchs 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore.
Researchers from Roswell Park Cancer Institute conducted both in vitro (outside the body) and in vivo (inside the body) studies to determine the effects of calcitriol and the analogs, QW-1624-F2-2 and paricalcitol, on the prevention of prostate cancer.
Calcitriol is the active metabolite of vitamin D, and is used clinically to treat a variety of disorders, including recent clinical trials for established cancer. A major obstacle to clinical use of calcitriol is dose-limiting hypercalcemia (abnormally high concentration of calcium in the blood). QW, developed at Johns Hopkins University and paricalcitol (Zemplar) have been shown to reduce parathyroid hormone levels (which regulate the metabolism of calcium and phosphorus in the body).
Warren Froelich | EurekAlert!
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