Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus. The research suggests that a microbicide using compounds that inhibit the processes by which HIV attaches to and enters target cells could potentially provide a safe, effective and practical way to prevent HIV transmission in women, according to study investigators. The study, published online October 30 in the journal Nature was funded principally by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.
Additionally, in a first-of-its-kind joint announcement, two of the worlds leading pharmaceutical companies, Merck & Co. and Bristol-Myers Squibb (BMS) today announced that they have signed separate license agreements with the International Partnership for Microbicides to develop two of the compounds evaluated in the study as potential vaginal microbicides to protect women from HIV. Under the agreements, Merck and BMS each will grant the non-profit group a royalty-free license to develop, manufacture and distribute their compounds for use as microbicides in resource-poor countries. Announced on the eve of the TIME Global Health Summit, this agreement marks the first time any pharmaceutical company has licensed an anti-HIV compound for development as a microbicide when the class of drugs is so early in development.
Women make up nearly half of all people living with HIV worldwide, and 80 percent of new cases of HIV infection in women result from heterosexual intercourse. A vaginal gel containing microbicides could be applied topically to reduce the transmission of HIV and other sexually transmitted infections.
Fran Simon | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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