In the event of an influenza pandemic, the worlds vaccine manufacturers will be in a race against time to forestall calamity. But now, thanks to a new technique to more efficiently produce the disarmed viruses that are the seed stock for making flu vaccine in large quantities, life-saving inoculations may be available more readily than before. The work is especially important as governments worldwide prepare for a predicted pandemic of avian influenza.
Writing this week (Oct. 31, 2005) in the online edition of the Proceedings of the National Academies of Science (PNAS), a team of researchers from the University of Wisconsin-Madison and the University of Tokyo report a new way to generate genetically altered influenza virus. The lab-made virus - whose genes are manipulated to disarm its virulent nature - can be seeded into chicken eggs to generate the vaccine used in inoculations, which prepare the human immune system to recognize and defeat the wild viruses that spread among humans in an epidemic or pandemic.
In their report, a team led by UW-Madison virologists Yoshihiro Kawaoka and Gabriele Neumann, describes an improved "reverse genetics" technique that makes it easier to make a seed virus in monkey kidney cells, which, like tiny factories, churn out millions of copies of the disarmed virus to be used to make vaccines.
Yoshihiro Kawaoka | EurekAlert!
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On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
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