Botulinum toxin can ease intense facial pain
There is another use for botulinum toxin which has brought relief to some who suffer from migraines and eye spasms. Botulinum toxin can also successfully treat intense facial pain called trigeminal neuralgia, according to a study published in the October 25, 2005, issue of Neurology, the scientific journal of the American Academy of Neurology.
Trigeminal neuralgia is a disorder characterized by sudden, severe, stabbing, or shock-like pain usually felt on one side of the jaw or cheek. The pain lasts several seconds and could be repeated in a series of attacks. Activities like talking, brushing teeth, or swallowing can trigger an attack. Also called tic douloureux, the disorder is more common in women than in men and typically affects those older than 50. Anticonvulsant medication has been a main course of treatment. In some cases, surgery is an option.
Researchers in Brazil and the United States studied the effects of botulinum toxin type A in 13 patients with trigeminal neuralgia. Pain significantly decreased in all patients 10 days following the injection. After 20 days, they were almost symptom-free.
By 60 days, four patients had become medication-free, and the others reduced their medication use by more than 50 percent.
"Drugs are not always effective in treating trigeminal neuralgia. Some patients avoid them because of side effects, and then their pain is more intense and longer-lasting," said Elcio Juliato Piovesan, MD, a neurologist at the Hospital of Clinics at Federal University of Parana in Curitiba, Brazil.
There were no major side effects from botulinum toxin observed in the 13 patients.
"A placebo-controlled clinical trial is needed to confirm our findings, including a follow-up period longer than 60 days," said Piovesan.
Marilee Tuite | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
Layered 2D material improves efficiency for solar cells and LEDs
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...