In a major research initiative funded by The Terry Fox Foundation, Claude Perreault, Canada Chair in Immunobiology at the Institute of Research in Immunology and Cancer (IRIC) of the Université de Montréal, has succeeded in developing a new approach to eradicate malignant melanoma tumours in mice. The findings of Dr. Perreault and his research team are reported in an article just published in the online edition of Nature Medicine, and soon to be published in the print edition of the publication.
In brief, the method developed by Perreault consists of administering T-lymphocytes – cells whose function it is to recognize and destroy abnormal cells – from a healthy mouse donor to mice with cancer. These lymphocytes are pre-immunized against a specific antigen (H7a) present in host mouse cancer cells. Although the target antigen is found in some of the host’s healthy cells, the treatment does not cause any side effects because the anti-H7a lymphocytes cluster almost exclusively around the tumour site where they are attracted to the molecule VCAM-1 present on the blood vessels that irrigate the tumour. The T-lymphocytes produce interferon gamma and perforine/granzyme to eradicate cancerous cells.
"We are very pleased with the insights yielded to date from this research project which our team initiated in 2003, explains Dr. Perreault. Thanks to another five-year grant from the Canadian Cancer Society, we have moved on directly to explore the cancer-curing potential of this immunotherapeutic method in the treatment of human melanoma. We may be only a few years away from testing the application on human beings. The prospect of this work leading to the development of an effective, nontoxic and non-invasive therapy against certain types of cancer for broad clinical use is exciting for every basic research students, scientist and doctors working on this project."
"Malignant melanoma is a devastating disease, affecting 4,300 Canadians this year and leading to 880 deaths. In fact, melanoma rates are increasing for both women and men," said Dr. Michael Wosnick, executive director of the National Cancer Institute of Canada, the research arm of the Canadian Cancer Society and The Terry Fox Foundation. "For these reasons, these results are promising and if proven successful in human clinical trials, this therapy could have a tremendous impact on the treatment of this disease."
About the Institute for Research in Immunology and Cancer (IRIC)
IRIC is an internationally-competitive systems biology research centre dedicated to cancer research. It is led by a group of elite scientists from Canada, Europe and the United States and engages in ambitious cross-disciplinary collaborations to tackle some of the greatest obstacles to human health we are faced with today. IRIC opened its doors at the heart of the University de Montréal campus in spring 2005 and is expected to double in size over the coming years, bringing together some 40 research teams -- for a total of some 500 scientists, postdoctoral trainees, graduate students, professionals and administrative staff -- by 2008.
About the National Cancer Institute of Canada
Funded by the Canadian Cancer Society and The Terry Fox Foundation, the National Cancer Institute of Canada is the longest-standing and most prestigious Canadian research organization devoted to advancing cancer control. This year, the Institute is providing $63 million to support excellent cancer research and related programs across the country.
About Université de Montréal
Founded in 1878, the Université de Montréal, with its two affiliated schools, the École Polytechnique and the HEC Montréal, is now the largest university in Quebec and the second largest in Canada. With over 55,000 students from around the world and some 10,000 employees, the Université de Montréal awards close to 10,000 diplomas at every university level. Deeply rooted in Montreal and dedicated to its international mission, the Université de Montréal is one of the top universities in the Frenchspeaking world.
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy