Anaesthetic agents are potentially dangerous drugs, and major patient complications can occur. If the patient is overdosed, death or major body organ damage can occur. Conversely, if the patient is under-dosed, patient awareness can occur. There is a narrow drug concentration “window” for both drug safety and anaesthetic efficacy, and the development of ways in which to monitor drug delivery concentration has been a major driver in anaesthetic agent safety research.
The Oxford invention has met this anaesthesia challenge by using modified statistical techniques to classify the physiological state of a human or animal subject. The classification monitors changes in the physiological state that occur over time either spontaneously or from external stimuli. Analysis of data obtained from anaesthetic trials has demonstrated the efficacy of the method for monitoring the depth of anaesthesia.
As well as using encephalograms the invention may be used advantageously with other forms of physiological data: electromyography to indicate muscle activity; analysis of images from magnetic resonance, computed tomography, X-ray and ultrasound; electrocardiography for blood pressure and blood oxygenation. The method also has many other applications including the monitoring of: consciousness, sleep, neuropathology, cerebral intoxication, cognitive state and muscle tremor.
David Eastham | alfa
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
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