Anaesthetic agents are potentially dangerous drugs, and major patient complications can occur. If the patient is overdosed, death or major body organ damage can occur. Conversely, if the patient is under-dosed, patient awareness can occur. There is a narrow drug concentration “window” for both drug safety and anaesthetic efficacy, and the development of ways in which to monitor drug delivery concentration has been a major driver in anaesthetic agent safety research.
The Oxford invention has met this anaesthesia challenge by using modified statistical techniques to classify the physiological state of a human or animal subject. The classification monitors changes in the physiological state that occur over time either spontaneously or from external stimuli. Analysis of data obtained from anaesthetic trials has demonstrated the efficacy of the method for monitoring the depth of anaesthesia.
As well as using encephalograms the invention may be used advantageously with other forms of physiological data: electromyography to indicate muscle activity; analysis of images from magnetic resonance, computed tomography, X-ray and ultrasound; electrocardiography for blood pressure and blood oxygenation. The method also has many other applications including the monitoring of: consciousness, sleep, neuropathology, cerebral intoxication, cognitive state and muscle tremor.
David Eastham | alfa
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
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A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy