Anaesthetic agents are potentially dangerous drugs, and major patient complications can occur. If the patient is overdosed, death or major body organ damage can occur. Conversely, if the patient is under-dosed, patient awareness can occur. There is a narrow drug concentration “window” for both drug safety and anaesthetic efficacy, and the development of ways in which to monitor drug delivery concentration has been a major driver in anaesthetic agent safety research.
The Oxford invention has met this anaesthesia challenge by using modified statistical techniques to classify the physiological state of a human or animal subject. The classification monitors changes in the physiological state that occur over time either spontaneously or from external stimuli. Analysis of data obtained from anaesthetic trials has demonstrated the efficacy of the method for monitoring the depth of anaesthesia.
As well as using encephalograms the invention may be used advantageously with other forms of physiological data: electromyography to indicate muscle activity; analysis of images from magnetic resonance, computed tomography, X-ray and ultrasound; electrocardiography for blood pressure and blood oxygenation. The method also has many other applications including the monitoring of: consciousness, sleep, neuropathology, cerebral intoxication, cognitive state and muscle tremor.
David Eastham | alfa
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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