Obesity, history of weight gain could help predict prostate cancer progression
How heavy a man is at the time he is diagnosed with prostate cancer, as well as his history of weight gain, appear to play significant roles in how aggressive his cancer may become, say researchers at The University of Texas M. D. Anderson Cancer Center.
While a link between weight and initial development of prostate cancer already has been made, this report, published in the Oct. 1 issue of Clinical Cancer Research, is the first to associate a mans body mass at different ages and adult weight gain with the risk of progression after his prostate cancer has been surgically treated.
"These findings support the view that the development of aggressive forms of prostate cancer may be influenced by environmental effects that occur early in life," says the studys lead researcher Sara Strom, Ph.D., an associate professor in the Department of Epidemiology.
Given further validation of the results, Strom suggests a mans history of body weight should be a factor oncologists consider when designing a treatment plan for patients newly diagnosed with prostate cancer.
The data also suggest that interventions such as diet and exercise could be a way to reduce the risk of prostate cancer progression, Strom says.
Researchers based their findings on outcomes from 526 M. D. Anderson prostate cancer patients treated by surgery (prostatectomy). They followed the progress of the patients for an average of 4 1/2 years, checking whether the men entered "biochemical failure" or a rising prostate specific antigen (PSA) level, which can indicate the cancer is advancing.
"After surgery, a patients PSA should go back to being undetectable, but if it begins to rise, that is an indicator of progression," Strom says. "Thirty percent of men who have biochemical failure will develop a life-threatening cancer metastasis, and so PSA is the only marker we have as yet to predict whose cancer will spread."
Within the group, 18 percent of the patients went into biochemical failure. Researchers then correlated an individuals risk of experiencing that failure with his weight history. They found that:
- Men who were obese (body mass index [BMI] of 30 or more) when they were diagnosed with prostate cancer were more likely to experience biochemical failure than those who were not obese;
- Patients who were obese at age 40 had an even greater rate of biochemical failure; and
- Men who gained weight at the greatest rate between age 25 and the time of their diagnosis experienced disease progression significantly sooner (an average of 17 months) than those men who gained weight more slowly (an average of 39 months).
Strom says that it is currently unclear how excess obesity contributes to prostate cancer progression, although leading theories suggest it could be linked to changes in a number of different hormones (such as androgen and growth factors) and/or lifestyle behaviors (such as poor diet and inadequate physical activity). But she adds that "understanding the mechanisms by which weight gain contributes to prostate cancer progression will lead to rationally designed preventive strategies."
Stephanie Dedeaux | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Mapping the interaction of a single atom with a single photon may inform design of quantum devices
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...