Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genotype Of Hypertensive Patient Determines Treatment Success

13.09.2005


Success of hypertension treatment depends on how well the chosen treatment mode matches the patient’s genotype. Specialists of the Chair of Balneology and Physical Therapy (Kirov Army Medical College) have determined how the hypertensive patient’s genotype impacts the efficiency of magnetic-laser therapy.



Primary hypertension is one of the most frequent diseases, the treatment of which is still a problem to contemporary medicine. The disease is determined by some genes, each of the genes may exist in several variants. Respective combination of these genes forms the so-called “risk threshold” of disease origin. The major contribution to the hypertension evolution is made by the genes of angiotensinogen (AGT), angiotensin converting enzyme (ACE) and some others. Their combination determines not only the risk of disease occurrence, but also a potential success of its treatment. Thus, adrenolytic drugs act differently on central hemodynamics depending on the AGT and ACE genes’ polymorphism. Besides drug therapy, there exist physical treatment modes, specifically - magnetic-laser therapy. The St. Petersburg physicians have researched how its effectiveness depends on genotype.

Magnetic-laser therapy effectiveness was evaluated with 101 patients with different variants of genes’ polymorphism. The polymorphism itself was determined with the help of the polymerase chain reaction, having taken some venous blood from the patients. Participants to the experiment underwent a radiation treatment course consisting of ten everyday sessions, the patients being examined before and after the course. Physicians watched the blood pressure changes within 24 hours and the reaction to physical activity (the patients were placed on the bicycle ergometer). Polymorphism of different genes determines the clinical behavior and treatment effectiveness to different extent. Magnetic-laser therapy helps the majority of hypertensive patients. The ACE gene has the highest influence on the magnetic-laser therapy results. In case of one variant of polymorphism (it is called MM- polymorphism) the blood pressure falls down to the greatest degree. The researchers have also found the combinations where the effect is the lowest (this is TT-polymorphism of the angiotensinogen gene). It is interesting to note that the variant of angiotensin converting enzyme (ACE) polymorphism is the worst for success of magnetic-laser therapy but it is optimal for drug treatment of high blood-pressure.


There are several genes that determine effectiveness of hypertension treatment. To clearly perceive their joint impact it is necessary to continue the research. However, it is evident already which genes determine to the largest extent the blood pressure and the value the blood pressure can be lowered in this or that way. Probably the patients will be soon undergo genetic blood test first, and then, depending on its results, the treatment will be prescribed.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>