Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genotype Of Hypertensive Patient Determines Treatment Success

13.09.2005


Success of hypertension treatment depends on how well the chosen treatment mode matches the patient’s genotype. Specialists of the Chair of Balneology and Physical Therapy (Kirov Army Medical College) have determined how the hypertensive patient’s genotype impacts the efficiency of magnetic-laser therapy.



Primary hypertension is one of the most frequent diseases, the treatment of which is still a problem to contemporary medicine. The disease is determined by some genes, each of the genes may exist in several variants. Respective combination of these genes forms the so-called “risk threshold” of disease origin. The major contribution to the hypertension evolution is made by the genes of angiotensinogen (AGT), angiotensin converting enzyme (ACE) and some others. Their combination determines not only the risk of disease occurrence, but also a potential success of its treatment. Thus, adrenolytic drugs act differently on central hemodynamics depending on the AGT and ACE genes’ polymorphism. Besides drug therapy, there exist physical treatment modes, specifically - magnetic-laser therapy. The St. Petersburg physicians have researched how its effectiveness depends on genotype.

Magnetic-laser therapy effectiveness was evaluated with 101 patients with different variants of genes’ polymorphism. The polymorphism itself was determined with the help of the polymerase chain reaction, having taken some venous blood from the patients. Participants to the experiment underwent a radiation treatment course consisting of ten everyday sessions, the patients being examined before and after the course. Physicians watched the blood pressure changes within 24 hours and the reaction to physical activity (the patients were placed on the bicycle ergometer). Polymorphism of different genes determines the clinical behavior and treatment effectiveness to different extent. Magnetic-laser therapy helps the majority of hypertensive patients. The ACE gene has the highest influence on the magnetic-laser therapy results. In case of one variant of polymorphism (it is called MM- polymorphism) the blood pressure falls down to the greatest degree. The researchers have also found the combinations where the effect is the lowest (this is TT-polymorphism of the angiotensinogen gene). It is interesting to note that the variant of angiotensin converting enzyme (ACE) polymorphism is the worst for success of magnetic-laser therapy but it is optimal for drug treatment of high blood-pressure.


There are several genes that determine effectiveness of hypertension treatment. To clearly perceive their joint impact it is necessary to continue the research. However, it is evident already which genes determine to the largest extent the blood pressure and the value the blood pressure can be lowered in this or that way. Probably the patients will be soon undergo genetic blood test first, and then, depending on its results, the treatment will be prescribed.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>