Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Metabolic syndrome: obesity, hypertension, diabetes and now also inflammation

12.09.2005


Metabolic syndrome is a combination of several individual metabolic problems that lead to high risk of atherosclerosis and heart problems. The disease has become a serious global problem in the last two decades with as much as 47 millions of cases in US and 25 million in Europe, and further understanding of its origin and mechanism is urgent. To that aim, in an article just published online in the International Journal of Obesity, a group of Portuguese scientists reports that patients suffering from severe metabolic syndrome show high levels of Protein-C reactive (CRP), an inflammatory marker, a result that suggests a role for inflammation in the disease. Additionally, it was also found that central obesity (found around the abdomen/organs) and high blood pressure, two of the metabolic problems associated with the syndrome, were directly associated with the increase in CRP levels making them into preferential targets for both therapy and prevention.



Metabolic syndrome was first described 80 years ago as a cluster of three or more specific health conditions in an individual that leads to high risk of cardiovascular disease. The health conditions associated with the syndrome (also called syndrome’s components) include obesity (especially central obesity, which is found around the viscera/abdomen), type 2 diabetes, insulin resistance, abnormal amounts of fat in the blood and high blood pressure (hypertension).

For most patients the origin of the syndrome seems to be related with poor nutrition, lack of physical activity and subsequent increase in body weight, and the raise in metabolic syndrome numbers is believed to be associated with the global epidemic of obesity and diabetes. The disease spreading has led to serious health concerns, especially in relation to the increased risk of cardiovascular problems observed in patients, and consequently to the realisation that better preventive and therapeutic measures were necessary.


CRP is a protein produced and released by the liver during inflammation that has recently been associated with increased risk for hypertension and heart disease. The amount of CRP produced in the body varies from person to person and is affected by the individual’s genetic makeup and lifestyle. Higher CRP levels tend to be found in individuals who smoke, have high blood pressure, are overweight and don’t exercise, whereas lean, athletic individuals tend to have lower CRP levels.

High CRP levels (although within the normal range/within the basal level) have also been associated with metabolic syndrome and, furthermore, with several of the syndrome’s individual components what led Ana-Cristina Santos, Henrique Barros and colleagues from the Department of Hygiene and Epidemiology, University of Porto Medical School, Portugal to decide to further investigate the relationship between the levels of this protein and metabolic syndrome.

The group of scientists studied 1022 individuals aged between 18 to 92 and found that, as previously proposed by others, metabolic syndrome patients present higher CRP levels than normal, healthy individuals. Additionally, it was observed that individuals with a higher number of syndrome’s components (and consequently a more severe disease/syndrome) would show higher CRP levels. These results support the view that inflammation is an important part of metabolic syndrome and led Santos, Barros and colleagues to propose that anti-inflammatory drugs, following further research, might be included in disease therapy.

Furthermore, the finding that central obesity and hypertension are the main syndrome’s components associated with high CRP levels further highlights the need to control these two metabolic problems and their importance as main targets for prevention and therapy measures.

Piece researched and written by: Catarina Amorim (catarina.amorim@linacre.ox.ac.uk)

Catarina Amorim | alfa
Further information:
http://www.nature.com/ijo/journal/vaop/ncurrent/abs/0803035a.html

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>