Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Incremental cost-effectiveness of 2 drug-eluting stents compared to a new generation bare-metal stent in a ‘real-world’ setting

06.09.2005


Repeat interventions to treat restenosis are the Achilles heal of stenting. The new drug-eluting stents (DES) have reduced the need for repeat interventions significantly compared to bare-metal stents (BMS), however, they are so much more expensive, that their use in all patients threatens to ‘kill’ hospital budgets. This has led to difficult discussions among physicians, patients and hospital administrators with regard to who should or could get DES and it was questioned whether withholding DES for cost reasons would not be rationing.



The prospective, randomised, controlled Basel stent cost effectiveness trial (BAsel Stent Kosten Effektivitäts Trial, BASKET) answers these questions for the first time based on 826 consecutive patients treated with PCI and stenting at the University Hospital of Basel, Switzerland. Results presented in Stockholm will show whether DES are worth their price in all patients or whether at least certain patient groups can be identified in which they are cost-effective.

All patients treated with PCI and stenting over a one year period were randomised to receive a DES or a BMS irrespective of indication and risk for restenosis. Three fifths of patients presented with acute infarction or unstable coronary disease and more than two thirds had multivessel disease, not different between the three groups. Patients were treated with nearly two stents each for a total stent length of more than 30 mm per patient.


All patients were followed for 6 months for occurrence of death, non-fatal infarction and target vessel revascularization as well as for cost (baseline, stent and follow-up costs). Results will be presented as difference in costs between DES and BMS in relation to difference in major cardiac events between the two stent types and among the two DES tested. Subgroup analyses will indicate whether this incremental cost-effectiveness ratio is different in certain high risk subgroups such as patients with multivessel disease, small treated vessels, diabetes, long treated segments or those treated in acute coronary syndromes compared with low risk patients.

These findings may have an important impact on the use of DES in daily practice in view of their high cost and also on preferences for one of the two DES. This is particularly true since BASKET was performed entirely independently from the device industry, a reason why the eagerly awaited detailed results can only be revealed in Stockholm.

Gina Dellios | alfa
Further information:
http://www.escardio.org
http://www.escardio.org/vpo/ESC_congress_information/ConferenceReleases/

More articles from Health and Medicine:

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

nachricht ASU scientists develop new, rapid pipeline for antimicrobials
14.12.2017 | Arizona State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>