Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Modified collagen could yield important medical applications

31.08.2005


Altered protein could help deliver drugs and shape the growth of engineered tissue



Collagen often pops up in beauty products and supermodel lips. But by mating collagen with a molecular hitchhiker, materials scientists at Johns Hopkins hope to create some important medical advances. The researchers have found a simple new way to modify collagen, paving the way for better infection-fighting bandages and a treatment to block the formation of unwanted scar tissue. In addition, tissue engineers may be able to use modified collagen in the lab to help control the formation of tiny new blood vessels that can be used to promote the integration of tissue implants in patients.

Michael (Seungju) Yu of the university’s Whiting School of Engineering was scheduled to describe the new collagen modification process and its potential medical uses in an Aug. 30 presentation in Washington, D.C., at the 230th annual meeting of the American Chemical Society. His team also published a paper on the work earlier this year in the Journal of the American Chemical Society.


The research focuses on the human body’s most common protein. Collagen promotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. Because it is non-toxic, dissolves naturally over time and rarely triggers rejection, collagen is commonly used in cosmetics, drug delivery systems and biocompatible coatings.

Yu’s goal is to change some of collagen’s biochemical or mechanical properties to give it new medical applications. Traditionally, scientists have altered collagen by using intense heat or chemical reactions, techniques that may damage the protein or limit its safe use in humans. Yu’s method, however, requires only physical mixing of collagen with even smaller molecules called collagen mimetic peptides.

"That’s the beauty of this," said Yu, an assistant professor in the Department of Materials Science and Engineering. "If you want to attach these molecules to collagen, you don’t have to cook it or use harsh chemicals. You just mix them together in a solution."

In lab experiments, Yu and his colleagues have shown that this kind of molecular marriage does take place. They attached fluorescent tags to the peptides and observed the glow in collagen that had been mixed with the smaller molecules. Exactly how and why the collagen and the peptides join is uncertain. But researchers know that collagen molecules form a distinctive triple-helix in which three long protein strands intertwine like rope. Yu speculates that because the smaller collagen mimetic peptides have a propensity to make similar triple-helix structures, they are naturally attracted to collagen molecules. He believes the peptides make themselves at home within gaps formed by loose collagen strands.

This linkup opens the door to new medical treatments, Yu says, because it is easy to attach bioactive agents to the peptides. When the peptides bind with collagen, these attached agents can dramatically change the way collagen behaves in the body. For example, collagen normally attracts cells to close up a wound and form scar tissue. But this property is not always desirable; a clot can be dangerous inside a blood vessel or at certain injury sites, where scar tissue can interfere with the formation of new nerve connections.

Modified collagen can follow a different course. In their recent journal paper, Yu and his colleagues reported that they had attached a chemical, polyethylene glycol, to the peptides, causing collagen to repel cells instead of attracting them. When the researchers added human cells to a lab dish, the cells migrated toward an untreated collagen film but avoided the modified collagen sample. This form of collagen could stop the formation of blood clots and scar tissue, and scientists may be able to use it to control the shape and organization of cells and tissue that are grown in a lab, Yu says.

Still other medical uses are possible. A growth factor joined to collagen could encourage new cells to multiply. An antibiotic attached to collagen could help a collagen-based bandage fight infections over a long period of time. Modified collagen could also release helpful medications while serving as a coating for surgical tools and implants.

"With this process," Yu said, "we can make the collagen that’s already found in the human body behave in new ways, including some ways that are not found in nature. Modified collagen can give us great new tool for treating injuries and illnesses."

Phil Sneiderman | EurekAlert!
Further information:
http://www.jhu.edu

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>