Patients with primary biliary cirrhosis who are treated with methotrexate have an increased risk of death, according to a new systematic review of studies.
In five randomized controlled trials involving 457 people, the authors report that for patients treated with methotrexate, as a single therapy or in combination with other drug treatment, pooled data showed a tendency toward an increased risk of death or liver transplantation. The brand names for methotrexate are Rheumatrex and Trexall.
“ We do not advocate the use of methotrexate for patients with primary biliary cirrhosis,” conclude lead investigator Yan Gong, M.D., of Copenhagen University Hospital in Denmark and colleagues.
Yan Gong | EurekAlert!
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