Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Wheezing children: what is the best treatment?

10.08.2005


The treatment of a lung condition that affects almost half of all pre-school children is to be investigated by researchers at the Universities of Nottingham and Leicester.



They aim to find a definitive answer on the best way of treating the tens of thousands of children brought into hospitals every year with unexplained wheezing and shortness of breath.

The condition affecting them, known as ‘viral-induced wheezing’, is one of the commonest reasons for young children to be admitted to accident and emergency departments.


For many years, the standard treatment for this condition has been a short course of steroids — the same treatment commonly given to children suffering asthma symptoms.

But while asthma is thought to be triggered by allergies, viral-induced wheezing has different causes. And evidence has been accumulating recently that steroids may not, in fact, be the best approach for young children brought into hospital with viral-induced wheezing.

Researchers at the Universities of Nottingham and Leicester are now to investigate the treatment and establish definitively whether steroids are the best treatment or not.

Dr Jonathan Grigg and Dr Monica Lakhanpaul, both of the University of Leicester, are leading the study. Dr Grigg said: “By combining expertise at Leicester and Nottingham we will be able to recruit a large number of children into the study.

“Its results will therefore be robust enough to have an immediate impact on clinical care.”

Steroids work by reducing inflammation in the airways. But repeated doses can suppress the body’s own natural steroid production, which can have side effects on growth. So if the treatment were actually ineffective for viral-induced wheezing, such side-effects would be suffered unnecessarily.

Up to 700 children are to be enrolled onto the study from Nottingham’s City Hospital, the Queen’s Medical Centre, and Leicester Royal Infirmary over a three-year period. Half will be given steroids and half a placebo, and they will be followed up at one week after treatment and again at four weeks.

The study is being funded with a £200,000 grant from national charity Asthma UK.

Principal investigators at the University of Nottingham are Dr Alan Smyth and Professor Terence Stephenson.

Dr Smyth, senior lecturer in child health, said: “One of the commonest causes for pre-school children to be admitted to hospital is wheezing, and these children are frequently given steroids.

“Because they are effective in some similar conditions, there has been an assumption that steroids will work for viral-induced wheeze. But perhaps we haven’t been right in that assumption.

“We hope to answer an important clinical question, and provide a conclusive answer to the question of what is the best treatment to give to these children.”

Jenny Versnel, Assistant Director Research at Asthma UK said: “Asthma UK welcomes this study to address the uncertainty surrounding the efficacy of oral steroids in children where wheezing is associated with viral infections such as colds.

“It is hoped that results from this study will inform current practice.”

Dr Alan Smyth | alfa
Further information:
http://www.nottingham.ac.uk

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>