Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New materials and coatings extend life of vascular implants

10.08.2005


Research on new materials and coatings in EUREKA project E! 2866 VASCUCHARGE will extend the life of synthetic vascular grafts from months to years, saving on average €7,000 per operation. As such grafts are used in around 500 out of each million vascular treatments in Europe, the savings could be considerable. Furthermore, the pain and discomfort suffered by patients is significantly reduced, as is the drain on health service resources.

The number of implants used in the surgical treatment of vascular disease has been steadily increasing over the last 20 years, so it is now considered a common procedure. Such tubes replace or bypass part of a blood vessel – principally arteries – and operate in a similar fashion to natural blood vessels.

However, while advances have been made in vascular disease surgery, synthetic implants are still susceptible to thrombosis or clotting, occlusions and infection caused by protein and cell adsorption and coagulation activation. Serious post-surgical problems occur in some 10% of surgical patients, which includes approximately a 2% rate of vascular graft infections. As a result, some grafts have to be replaced after only a few months.



Project partners from Austria and Slovenia concentrated their efforts on small grafts where the problem is particularly acute – those with a diameter less than 6 mm. Improved grafts will diminish the likelihood of complications, so the need for repeat vascular surgical treatments will be greatly reduced.

“Little was known about the mechanisms that cause this undesired protein absorption before our work began,” explains Professor Dr Volker Ribitsch from the Institute of Chemical Process Development and Control at Austrian project partner Joanneum Research.

“We knew that there was a correlation between surface charge, surface energy and the accumulation of bioactive substances. By working closely with our Slovenian partners, we investigated these parameters and other factors, including the structure of the polymer used in the graft and a variety of coatings – such as heparin and collagen – to determine the conditions that can reduce this damaging protein absorption.”

New test device

While studying the grafts, the partners also developed a test device to make the necessary experimental investigations possible. “The new instrument monitors surface properties and protein adsorption on medical devices and provides continuous data,” says Professor Ribitsch. “It will be on the market and available to potential manufacturers in the next year or two.”

The new grafts and coatings require more research but are already promising to reduce replacement operations by up to 50%. When this essential work is complete, the partners will seek industrial collaboration with a medical equipment manufacturer to market the results.

“EUREKA was the ideal framework for the project as the expertise lay beyond the medical devices industry,” adds Ribitsch. “Its bottom-up approach is ideal for such research.” The budget for the project was €0.6 million.

Paul McCallum | alfa
Further information:
http://www.eureka.be/files/:722836
http://www.eureka.be

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>