Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ovarian cancer risk and consumption of milk products and lactose

08.08.2005


Meta-analysis of epidemiological studies finds some support for a link



An analysis of 21 studies that have investigated the link between ovarian cancer and the consumption of milk products and lactose has found some support for the hypothesis that high intake is associated with increased cancer risk. The results of this analysis, published online August 5, 2005 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), found that support was stronger in cohort studies, compared to case-control studies, which offered varying results.

Since a positive correlation between ovarian cancer risk and the consumption of milk products and lactose was first reported in 1989, many epidemiological studies have further examined the relationship. However, these studies have yielded conflicting conclusions. To better understand the uncertain relationship, researchers led by Susanna C. Larsson of the National Institute of Environmental Medicine at the Karolinska Institute in Sweden, conducted a meta-analysis of relevant case-control and cohort studies.


The researchers sought reports that offered data from a case-control, or cohort study on the association between intakes of milk, yogurt, cheese or lactose, and incidence of or mortality from epithelial ovarian cancer. Studies also had to present results as an odds ratio, or relative risk, with 95 percent confidence intervals. The researchers accepted three prospective cohort studies, and 18 case-control studies and performed a meta-analysis to determine associations between consumption and cancer risk.

Their analysis found notable differences between case-control and cohort studies. Case-control studies showed low-fat milk consumption negatively associated, and whole milk consumption positively associated, with the risk of ovarian cancer, but offered no support for the involvement of lactose in the development of ovarian cancer. By contrast, prospective cohort studies indicated that high intakes of milk may increase the risk of ovarian cancer. They also revealed a 13 percent increase in ovarian cancer risk with a daily increase of 10 grams of lactose, the approximate amount in one glass of milk. When case-control and cohort studies were considered in combination, yogurt consumption was associated with a non-significant increase in cancer risk, while cheese was not associated with risk.

The differences between the findings of case-control studies and those of cohort studies could be explained by a number of factors: selection bias, recall bias or changes in dietary practices after cancer diagnosis. They might also be due to the time interval between diet assessment and illness, since cohort studies may record dietary practices decades before illness occurs, while case-control studies assess diet around the time of diagnosis. Other limitations of this study include the observational nature of the assessed studies, imprecise measurements of diet, and publication bias.

Of note, the two studies that examined histological subtypes of ovarian cancer found that the associations with milk and lactose intakes were confined to serous ovarian cancer, leading researchers to advise, "future studies should consider specific subtypes of ovarian cancer, and the interrelationship between intakes of dairy foods and lactose, genetic polymorphisms, and ovarian cancer risk."

"In conclusion," they write, "prospective cohort studies, but not case-control studies, support the hypothesis that high intakes of dairy foods and lactose may increase the risk of ovarian cancer."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/ijc.
http://www.wiley.com

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>