Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Develop Heat Spreader for Epileptic Seizure Treatment Device

27.07.2005


Graphic courtesy of G. P. "Bud" Peterson


Rensselaer Polytechnic Institute researchers are developing a tiny, highly efficient heat spreader to be used in a new device to be implanted in the brain of patients who suffer from severe epileptic seizures. The implant device is designed to detect and arrest epileptic seizures as they begin by cooling a small region of the brain, thereby effectively blocking the erratic electrical activity.

G. P. “Bud” Peterson, provost and professor of mechanical, aerospace, and nuclear engineering at Rensselaer, and his team are collaborating with researchers at Washington University School of Medicine in St. Louis to design, model, test, and develop the implant device. The research and the potential of the device are featured in the July 16 issue of New Scientist.

The heat spreader being developed at Rensselaer utilizes a phase-change heat process, the same mechanism that the human body uses to cool itself, to transfer and distribute heat in the brain. The fundamental principal behind the operation of the heat spreader is evaporation and condensation, similar to perspiration. Using a pure substance, saturated conditions are created inside the heat pipe, resulting in evaporation in the heated regions. Heat entering the pipe turns the liquid water to vapor, which is forced along the pipe by high pressure where it is condensed in the cooler regions. The dissipated heat is then pushed out of the heat pipe, and the wicking structure pumps the liquid back to the evaporator.



“The heat spreader we created for this implant device acts as a very efficient thermal conductor, spreading and releasing the heat without minimal temperature increase, thereby preventing any potential tissue damage to the brain,” said Peterson. “The brain can tolerate temperature reductions on the order of 18 to 20°C without sustaining permanent damage. However, the brain cannot tolerate temperature increases over 0.5°C. This requires that the heat both absorbed and generated by the device be spread across a much larger surface area.”

Implanted on the neocortex of the brain, close to where erratic electrical activity is causing the epileptic seizure, the implant device is designed to detect the unusual level of electrical activity that accompanies these types of seizures. The implant device then is activated to cool a small area of the brain from approximately 38°C (100°F) to 20°C (68°F) to render that part of the brain temporarily non-functional and seizure-free, according to researchers.

The implant device works as a very small “thermoelectric refrigerator,” approximately 0.25 inches on a side, consisting of many tiny metal semiconductor junctions connected between two ceramic electrodes to create an electronic circuit. The result is an implantable device in which one side is cooled and other is heated as electrical current moves through it. The heat spreader being developed by Peterson and his team, allows the heat generated and absorbed by the implant device to be effectively released without a significant increase in temperature.

The implant device has been successfully tested on rats and has been approved by the National Institutes of Health (NIH) for testing in primates. Researchers expect the device will provide a new methodology for the treatment of epileptic seizures in humans.

Peterson has conducted research on heat pipes and related two-phase heat transfer devices for 25 years, holds eight patents, and is the author or co-author of more than 145 peer-reviewed journal articles in fields as diverse as electronics and spacecraft thermal control, energy recovery systems, biomedical applications, and the cooling of valve stems in internal combustion engines.

About Rensselaer

Rensselaer Polytechnic Institute, founded in 1824, is the nation’s oldest technological university. The university offers bachelor’s, master’s, and doctoral degrees in engineering, the sciences, information technology, architecture, management, and the humanities and social sciences. Institute programs serve undergraduates, graduate students, and working professionals around the world. Rensselaer faculty are known for pre-eminence in research conducted in a wide range of fields, with particular emphasis in biotechnology, nanotechnology, information technology, and the media arts and technology. The Institute is well known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

Tiffany Lohwater | EurekAlert!
Further information:
http://www.rpi.edu

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>