Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Environmental estrogen-like chemical is potent trigger for breast cancer

13.07.2005


New research published in the latest issue of the Journal of Applied Toxicology, shows that in experimental mice an estrogen-mimicking chemical, 4-nonylphenol, triggers breast cancer to a greater extent than naturally occurring estrogens based on their relative affinity for the estrogen receptor. 4-Nonylphenol is released into the environment from cleaning materials, textiles, plastics and some paper.



Breast cancer is the most commonly diagnosed cancer in women and environmental factors appear to cause about three-quarters of cases. Many of the environmental factors increase a woman’s levels of the hormone estrogen, which is thought to be a major contributing factor in the disease.

4-Nonylphenol mimics estrogen and is found in the environment, and researchers in the past have found it in drinking water and in some processed foods. In the liver it stimulates an enzyme system that in turn increases the production of estriol, a hormone associated with breast cancer. It also has an affinity for estrogen receptors in breast tissue that trigger growth, and this affinity is 4,000 times less than estrogens.


To assess its ability to cause breast cancer, a team of researchers at the University of Texas at El Paso and Clemson University in Southern Carolina, compared the effect of giving various doses of 4-nonylphenol and estrogen to mice.

In one set of experiments, they discovered that while 4-NP indeed stimulates estriol metabolism in the liver, it doesn’t lead to increased levels of estriol in the blood stream. The researchers conclude that as well as stimulating enzymes that in turn produce estriol, it must also have a direct inhibiting affect on estriol production.

In a second set of experiments, they gave a variety of doses of 4-NP or estrogen to mice that are genetically engineered to readily develop breast cancer. Monitoring them over 32 weeks, the researchers found that many of the mice given 4-NP developed breast cancer. Those given equivalent doses of estrogen based on the relative binding affinities of nonylphenol and estradiol for their receptor, did not develop mammary cancer.

“Long term exposure to 4-nonylphenol could leave individuals at a significantly increased risk of developing breast cancer,” says toxicologist William Baldwin, from the University of Texas at El Paso.

Polly Young | alfa
Further information:
http://www3.interscience.wiley.com/cgi-bin/jhome/2457

More articles from Health and Medicine:

nachricht Light beam replaces blood test during heart surgery
28.02.2017 | University of Central Florida

nachricht Cells adapt ultra-rapidly to zero gravity
28.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New technology offers fast peptide synthesis

28.02.2017 | Life Sciences

WSU research advances energy savings for oil, gas industries

28.02.2017 | Power and Electrical Engineering

Who can find the fish that makes the best sound?

28.02.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>