New research published in the latest issue of the Journal of Applied Toxicology, shows that in experimental mice an estrogen-mimicking chemical, 4-nonylphenol, triggers breast cancer to a greater extent than naturally occurring estrogens based on their relative affinity for the estrogen receptor. 4-Nonylphenol is released into the environment from cleaning materials, textiles, plastics and some paper.
Breast cancer is the most commonly diagnosed cancer in women and environmental factors appear to cause about three-quarters of cases. Many of the environmental factors increase a woman’s levels of the hormone estrogen, which is thought to be a major contributing factor in the disease.
4-Nonylphenol mimics estrogen and is found in the environment, and researchers in the past have found it in drinking water and in some processed foods. In the liver it stimulates an enzyme system that in turn increases the production of estriol, a hormone associated with breast cancer. It also has an affinity for estrogen receptors in breast tissue that trigger growth, and this affinity is 4,000 times less than estrogens.
Polly Young | alfa
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