Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Environmental estrogen-like chemical is potent trigger for breast cancer

13.07.2005


New research published in the latest issue of the Journal of Applied Toxicology, shows that in experimental mice an estrogen-mimicking chemical, 4-nonylphenol, triggers breast cancer to a greater extent than naturally occurring estrogens based on their relative affinity for the estrogen receptor. 4-Nonylphenol is released into the environment from cleaning materials, textiles, plastics and some paper.



Breast cancer is the most commonly diagnosed cancer in women and environmental factors appear to cause about three-quarters of cases. Many of the environmental factors increase a woman’s levels of the hormone estrogen, which is thought to be a major contributing factor in the disease.

4-Nonylphenol mimics estrogen and is found in the environment, and researchers in the past have found it in drinking water and in some processed foods. In the liver it stimulates an enzyme system that in turn increases the production of estriol, a hormone associated with breast cancer. It also has an affinity for estrogen receptors in breast tissue that trigger growth, and this affinity is 4,000 times less than estrogens.


To assess its ability to cause breast cancer, a team of researchers at the University of Texas at El Paso and Clemson University in Southern Carolina, compared the effect of giving various doses of 4-nonylphenol and estrogen to mice.

In one set of experiments, they discovered that while 4-NP indeed stimulates estriol metabolism in the liver, it doesn’t lead to increased levels of estriol in the blood stream. The researchers conclude that as well as stimulating enzymes that in turn produce estriol, it must also have a direct inhibiting affect on estriol production.

In a second set of experiments, they gave a variety of doses of 4-NP or estrogen to mice that are genetically engineered to readily develop breast cancer. Monitoring them over 32 weeks, the researchers found that many of the mice given 4-NP developed breast cancer. Those given equivalent doses of estrogen based on the relative binding affinities of nonylphenol and estradiol for their receptor, did not develop mammary cancer.

“Long term exposure to 4-nonylphenol could leave individuals at a significantly increased risk of developing breast cancer,” says toxicologist William Baldwin, from the University of Texas at El Paso.

Polly Young | alfa
Further information:
http://www3.interscience.wiley.com/cgi-bin/jhome/2457

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>