Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saturated fats combined with genetic trait implicated in development of type 2 diabetes

29.06.2005


Research being published in July issue of Diabetes zeros in on who is potentially more susceptible to developing the disease



A University of Alberta team of researchers has discovered an additional 2 million Canadians who have a high fat diet or are overweight may be at increased risk for developing type 2 diabetes if they carry a particular type of common specific genetic trait known as a polymorphism.

In work published today in the journal, Diabetes, pharmacology professor Peter Light and graduate student Michael Riedel suggest that saturated and trans fats are much more effective activators of a specific potassium channel found in the pancreas--known when activated to reduce insulin secretion from the pancreas and increase blood sugar levels. This effect, they say, is amplified in the polymorphic potassium channel. Interestingly, it seems that polyunsaturated fats are poor activators of the potassium channel.


"We’re suggesting that people with this specific potassium channel polymorphism--about 2 million Canadians--may be more susceptible to type 2 diabetes if they have a high fat diet or are overweight, two of the biggest risk factors for type 2 diabetes," Dr. Light explains. "This may explain why 20 percent of type 2 diabetic Caucasians carry two copies of this polymorphism in their genes compared to only 10 percent in the non-diabetic Caucasian population."

The researchers say this discovery opens up the distinct possibility of specific genetic screening of people at risk for type 2 diabetes, which would then give physicians additional information to advise their high-risk patients on preventative diet and exercise options.

About 10 percent of non-diabetic Caucasians who possess this polymorphism may be at increased risk of developing type 2 diabetes if they consume a diet rich in saturated and trans fats. These findings provide a plausible "missing link" between common genetic variations and environmental risk factors for this very prevalent disease, Dr. Light explains.

The most recent findings build on their previous work. Back in 2003, the group published a brief genetics report in Diabetes showing that this common polymorphism in a potassium channel that controls insulin secretion is much more susceptible to being activated by intracellular fats.

Michael Robb | EurekAlert!
Further information:
http://www.ualberta.ca

More articles from Health and Medicine:

nachricht New 3-D imaging reveals how human cell nucleus organizes DNA and chromatin of its genome
28.07.2017 | University of California - San Diego

nachricht Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Abrupt motion sharpens x-ray pulses

Spectrally narrow x-ray pulses may be “sharpened” by purely mechanical means. This sounds surprisingly, but a team of theoretical and experimental physicists developed and realized such a method. It is based on fast motions, precisely synchronized with the pulses, of a target interacting with the x-ray light. Thereby, photons are redistributed within the x-ray pulse to the desired spectral region.

A team of theoretical physicists from the MPI for Nuclear Physics (MPIK) in Heidelberg has developed a novel method to intensify the spectrally broad x-ray...

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

New 3-D imaging reveals how human cell nucleus organizes DNA and chromatin of its genome

28.07.2017 | Health and Medicine

Heavy metals in water meet their match

28.07.2017 | Power and Electrical Engineering

Oestrogen regulates pathological changes of bones via bone lining cells

28.07.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>