Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Functional MRI enables noninvasive evaluation of epilepsy patients

28.06.2005


Functional magnetic resonance imaging (fMRI) of the brain reduces the need for invasive testing of seizure disorder patients being considered for surgical treatment, according to a study published in the July issue of the journal Radiology.



"fMRI gives the surgical team an important roadmap of the brain function without contrast injections or invasive tests," said the study’s lead author, L. Santiago Medina, M.D., M.P.H., co-director of neuroradiology and director of the Health Outcomes, Policy and Economics Center at Miami Children’s Hospital. "This imaging technology is a powerful tool that improves surgical decision making in patients being considered for seizure surgery."

Dr. Medina’s study evaluated the effect of fMRI results on the diagnostic work-up and treatment planning of 60 consecutive seizure disorder patients, including 33 male and 27 female patients. The fMRI findings helped five patients avoid additional surgery and altered the extent of surgery in four others.


A seizure is an outward sign of a malfunction in the electrical activity of the brain. Seizures that occur more than once without special cause are called seizure disorder or epilepsy. According to the Epilepsy Foundation of America, 2.5 million Americans have been diagnosed with epilepsy.

Brain surgery has proven to be an effective treatment for patients with seizure disorders who do not respond to medication. The surgical treatment involves resecting, or cutting away, brain tissue that contains a seizure focus--the location in the brain where the seizures originate. Before resection surgery is performed, the treatment team uses diagnostic tests to help determine the proximity of a seizure focus to vital areas of brain function and to provide a map of the area.

Until recently, the Wada test and electrical cortical mapping--both invasive, costly tests that require large medical teams--were the only methods for identifying these critical areas. fMRI, which uses radio waves and a strong magnetic field, is a non-invasive test capable of identifying the location of critical brain functions that could be affected by the location of the seizure focus.

Based on fMRI results, five patients in Dr. Medina’s study avoided a two-stage surgery with extra-operative direct electrical stimulation mapping and instead received a one-stage resection surgery. The extent of surgical resection was altered in another four patients, because fMRI images identified critical areas of the brain close to the seizure focus.

Other changes in patient care based on fMRI results included:

  • The team altered patient and family counseling in 58 percent of patients;
  • Intraoperative mapping was altered in 52 percent of patients;
  • Overall surgical plans were altered in 42 percent of patients;
  • 63 percent of patients were able to avoid further studies, including the Wada test.

When the medical team reviewed functional MR images of the brain, they significantly changed the patient’s diagnostic and treatment plans," said neurologist Byron Bernal, M.D., co-author of the study. "With fMRI, the physician, patient and family have more information about important critical areas of brain function, helping them make more informed decisions."

Of the study’s 60 patients, 32 were not candidates for surgery or refused surgical treatment. Of the 28 patients who proceeded with surgery, 17 were seizure-free following the resection, and eight had a 50 percent to 90 percent reduction in seizures. Three of the surgical patients experienced less than a 50 percent reduction in seizures at six-month follow-up.

Doug Dusik | EurekAlert!
Further information:
http://www.rsna.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>