Expert from The Childrens Hospital of Philadelphia comments on blood test for malignant hyperthermia
A rare but potentially life-threatening inherited condition called malignant hyperthermia (MH) may strike surgical patients who receive common drugs for general anesthesia. Usually there is no outward sign of a problem before the drugs are given, but the drugs may trigger abnormal metabolic responses, such as a rapid rise in body temperature, muscle rigidity and other complications that may constitute a medical emergency.
Approximately one in 10,000 persons have a susceptibility to MH; most will not know this unless they receive general anesthesia. Currently, the only test for MH susceptibility requires a muscle biopsy done at a few specialized diagnostic centers. However, a newly offered genetic test requires only a blood sample from a patient suspected to be at risk for MH. The test detects 25 to 50 percent of the mutations known to make one susceptible to the condition. If physicians know that a patient has this genetic susceptibility, they can substitute other anesthesia drugs when surgery is required.
Joey Marie McCool | EurekAlert!
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
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