Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

One-A-Day Tablet Treats Common Infection

06.06.2005


A bioadhesive tablet containing the antifungal drug miconazole is an effective and convenient means of treating oropharyngeal candidiasis, which is the most frequently occurring infection in head and neck cancer patients undergoing radiation therapy, scientists report today at the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary.



Dr. Rene-Jean Bensadoun from Centre Antoine Lacassagne in Nice, and international colleagues, studied patients in 36 centers who had completed radiotherapy for head and neck cancer and had oropharyngeal candidiasis confirmed by examination or fungal culture.

One group of 141 patients were given daily a bioadhesive tablet containing 50mg of miconazole, developed by BioAlliance Pharma, a French biopharmaceutical company, the other 141 patients received a mouth gel (MBG) containing 125mg of miconazole four times daily for 14 days.


"We found that the daily bioadhesive buccal tablet achieved the same efficacy as the gel, but required one-tenth as much miconazole, and could be given on a much more convenient schedule," Dr. Bensadoun said.

"Patients currently need to apply the gel four times a day, which is disruptive to their day and increases the risk that they will miss treatments and suffer the discomfort of candidiasis for a longer period of time."

"While oropharyngeal candidiasis is perhaps not a dangerous infection, it is unpleasant, and anything we can do as oncologists to improve the quality of life of cancer patients is a positive thing."

"Head and neck cancer patients suffer not only from their disease, but experience many acute and chronic side-effects due to treatment", comments Dr. Dirk Schrijvers from the Department of Medical Oncology of the ZNA Middelheim, Antwerp, Belgium. Everything that can improve the quality of life of these patients during and after treatment will have an impact on treatment compliance and disease outcome. By providing a simpler way of controlling oral candidiasis, patient compliance may increase.

Gracemarie Bricalli | alfa
Further information:
http://www.esmo.org

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>