Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High blood pressure causes pathological scars in the heart

25.05.2005


Fibrosis (scar tissue formation) is the determinant lesion in the subsequent evolution of the heart in a patient with high blood pressure. This item appeared in the latest edition of Nature Clinical Practice Cardiovascular Medicine, a journal that is part of the Nature group. The article published heart research recently carried out at the University of Navarra.



When arterial blood pressure rises, we have what is known as high blood pressure and the heart becomes overloaded, as it were: it pumps blood against the greater resistance created by this extra pressure. During most of the XX century doctors believed that the growth of cardiac muscle (left ventricular hypertrophy or LVH) presented by patients with high blood pressure was beneficial for the heart. It was thought that this change enabled the pumping of blood with greater force, compensating for the greater resistance due to higher blood pressure.

However, clinical and epidemiological studies at the end of the last century revealed that high blood pressure patients with LVH showed more frequent and more severe cardiac complications than high blood pressure individuals without LVH. This led a number of clinical and basic research groups to the hypothesis that not everything was quite right with the idea that hypertrophy of the cardiac muscle was the answer to high blood pressure. They also believed that, masked by the hypertrophy, they might find decisive alterations which, in the long term, might suggest a prognosis of high blood pressure cases with LVH worse than those without. It was now thought that the heart in high blood pressure cases may suffer structural changes thus producing massive scarring (myocardial fibrosis).


Method for diagnosis and treatments

20 years ago it was thought that a progressive substitution of the heart muscle cells by inert fibres played a critical role in the deterioration of the heart and the appearance of clinical complications in high blood pressure patients. Over this period, the research team has provided evidence, from both animals and high blood pressure human patients that this hypothesis was, indeed, correct and proceeded to explore some possible mechanisms for this deterioration.

Researchers at CIMA and the Navarre University Hospital have developed a method for the bloodless diagnosis of myocardial fibrosis and have shown that certain pharmacological treatments not only prevent damage to the tissue, but also repair the tissue damaged.

30% of the adult world population has high blood pressure and half of these shows LVH and are, thus, prone to the consequences of myocardial fibrosis. This data means that, of the 8 million people with high blood pressure currently in Spain, 4 million have LVH and fibrosis. As outlined in Nature, doctors now have diagnostic means and pharmacological measures to prevent fibrosis of the heart in these 4 million citizens. Thus, this medical research offers a “message of hope” to the public at large.

Irati Kortabitarte | alfa
Further information:
http://www.elhuyar.com
http://www.basqueresearch.com

More articles from Health and Medicine:

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Molecule flash mob

19.01.2017 | Physics and Astronomy

Rabies viruses reveal wiring in transparent brains

19.01.2017 | Health and Medicine

Global threat to primates concerns us all

19.01.2017 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>