Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Birth Weight and Breastfeeding in Infancy May Affect Premenopausal Breast Cancer Risk

23.05.2005


Premenopausal women who were heavier than average at birth or had not been breastfed as infants appear to be at increased risk for developing breast cancer, epidemiologists at the University at Buffalo’s School of Public health and Health Professions have found.



Results of the study, which showed no association between birth weight and breastfeeding in infancy and postmenopausal breast-cancer risk, were reported at the American Association for Cancer Research annual meeting in Anaheim, Calif. "The intrauterine and neonatal life periods have been suggested as critical windows in mammary gland development," said Maddalena Barba, M.D., research instructor in the UB Department of Social and Preventive Medicine and lead researcher on the study. "In utero and early childhood exposures might affect breast cancer risk by altering the hormonal environment of the developing fetus and young infant through mechanisms not yet completely clarified."

Barba and colleagues from UB’s School of Public Health and Health Professions analyzed data collected from 2,382 women participating in the Western New York Exposures and Breast Cancer Study conducted from 1996-2001 during in-person, computer-assisted interviews. Complete information on the exposures of interest was available for 845 participants newly diagnosed with breast cancer during the study period who served as cases, and for 1,573 matched controls.


Researchers compared cases and controls, taking into consideration already well-recognized breast-cancer risk factors such as age, education, body-mass index, history of benign breast disease, family history of cancer, months of lactation, age at first menstrual period, age at first pregnancy, number of pregnancies and age at menopause for postmenopausal women.

Results showed that premenopausal women whose birth weight was greater than 8.5 pounds, and premenopausal women who had not been breast fed as infants, had an almost two-fold risk of developing breast cancer when compared to premenopausal women whose weight at birth was 5.5-7 pounds (reference category) and who had been breast fed.

None of these variables showed a relationship with postmenopausal breast cancer. Birth order was not associated with breast cancer risk in pre- or postmenopausal women. "Our results support the hypothesis that early life events impact women’s breast-cancer risk later in life," said Barba. "Further research based on targeted studies is needed to reach a deeper understanding of the underlying biological mechanisms."

Additional researchers on the study were Susan E. McCann, Ph.D., Jing Nie, Ph.D., Saverio Stranges, M.D., Ph.D., Barbara Fuhrman, Maurizio Trevisan, M.D., and Jo L. Freudenheim, Ph.D., from the Department of Social and Preventive Medicine, and Paola Muti, M.D., formerly at UB, currently at the Italian National Cancer Institute Regina Elena in Rome, Italy.

The research was supported in part by grants from the U.S. Army and the American-Italian Cancer Foundation.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.

Lois Baker | EurekAlert!
Further information:
http://www.buffalo.edu

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>