Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers seek methods to make new cancer therapies available more quickly

18.05.2005


Latest findings indicate one- and two-year study results not as predictive as longer-term studies



In their efforts to explore more effective and efficient ways to conduct clinical trials, Mayo Clinic cancer researchers will present new recommendations about how long studies should track results when evaluating new cancer therapies. An analysis led by Daniel Sargent, Ph.D., director of statistics for Mayo Clinic Cancer Center, shows that many study results garnered after three years are just as reliable as those produced after five years. But, data provided after two years of study are less precise, and those provided after only one year are not sufficiently reliable.

Dr. Sargent will present these results on May 17, during the 2005 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Fla. Dr. Sargent is one of the founders of the Adjuvant Colon Cancer Endpoints (ACCENT) Group that is studying whether there are ways to make results of clinical trials in oncology available more quickly, to provide effective treatments to patients faster.


"We found last year that outcomes after three years were highly predictive of the five-year outcomes, so we went back and asked ’could we look after one year or two years,’ " says Dr. Sargent. "Our new results suggest that two years is almost as good as three years, but that one year is too early."

Last year, Dr. Sargent presented his results on colon cancer therapies to the Food and Drug Administration (FDA), which agreed with his conclusions, and allowed three years of follow-up study to be part of the evidence in considering new drug therapies for colon cancer treatment. In the past, five years of follow-up had been required before results were considered definitive.

The recommendations from the study presented at the 2005 ASCO conference were based on the study of individual patient data from 20,898 patients and 18 randomized trials.

ACCENT is an international collaboration involving researchers throughout Europe, Canada and the United States. Dr. Sargent helped found the group about a year and a half ago to focus efforts on studies involving colon cancer. As ACCENT continues its work, it may broaden its focus to include other cancers, he said.

"We were dissatisfied with how long it takes to complete trials and make promising new therapies available to help patients," says Dr. Sargent. "Our goal was to see if there was a better and more efficient way to conduct the trials."

Dr. Sargent says the research is not perfect, and some therapies yield different results at three years than they do at five years. "We are committed to following patients for long-term outcomes, and if the results change with this further follow-up, we could modify treatment," he says. "The long-term health of the patient is still the ultimate goal."

DISCLOSURE: This study was funded by the National Cancer Institute (NCI) and coordinated by the North Central Cancer Treatment Group (NCCTG), a national clinical research group sponsored by the NCI. NCCTG is a network of more than 400 community-based cancer treatment clinics in the United States, Canada and Mexico that work with Mayo Clinic to conduct clinical studies for advancing cancer treatment.

Lee Aase | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Health and Medicine:

nachricht Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>