Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers seek methods to make new cancer therapies available more quickly

18.05.2005


Latest findings indicate one- and two-year study results not as predictive as longer-term studies



In their efforts to explore more effective and efficient ways to conduct clinical trials, Mayo Clinic cancer researchers will present new recommendations about how long studies should track results when evaluating new cancer therapies. An analysis led by Daniel Sargent, Ph.D., director of statistics for Mayo Clinic Cancer Center, shows that many study results garnered after three years are just as reliable as those produced after five years. But, data provided after two years of study are less precise, and those provided after only one year are not sufficiently reliable.

Dr. Sargent will present these results on May 17, during the 2005 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Fla. Dr. Sargent is one of the founders of the Adjuvant Colon Cancer Endpoints (ACCENT) Group that is studying whether there are ways to make results of clinical trials in oncology available more quickly, to provide effective treatments to patients faster.


"We found last year that outcomes after three years were highly predictive of the five-year outcomes, so we went back and asked ’could we look after one year or two years,’ " says Dr. Sargent. "Our new results suggest that two years is almost as good as three years, but that one year is too early."

Last year, Dr. Sargent presented his results on colon cancer therapies to the Food and Drug Administration (FDA), which agreed with his conclusions, and allowed three years of follow-up study to be part of the evidence in considering new drug therapies for colon cancer treatment. In the past, five years of follow-up had been required before results were considered definitive.

The recommendations from the study presented at the 2005 ASCO conference were based on the study of individual patient data from 20,898 patients and 18 randomized trials.

ACCENT is an international collaboration involving researchers throughout Europe, Canada and the United States. Dr. Sargent helped found the group about a year and a half ago to focus efforts on studies involving colon cancer. As ACCENT continues its work, it may broaden its focus to include other cancers, he said.

"We were dissatisfied with how long it takes to complete trials and make promising new therapies available to help patients," says Dr. Sargent. "Our goal was to see if there was a better and more efficient way to conduct the trials."

Dr. Sargent says the research is not perfect, and some therapies yield different results at three years than they do at five years. "We are committed to following patients for long-term outcomes, and if the results change with this further follow-up, we could modify treatment," he says. "The long-term health of the patient is still the ultimate goal."

DISCLOSURE: This study was funded by the National Cancer Institute (NCI) and coordinated by the North Central Cancer Treatment Group (NCCTG), a national clinical research group sponsored by the NCI. NCCTG is a network of more than 400 community-based cancer treatment clinics in the United States, Canada and Mexico that work with Mayo Clinic to conduct clinical studies for advancing cancer treatment.

Lee Aase | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>