‘Polypill’ improves survival rates for heart disease sufferers
A ‘polypill’ made up of a combination of drugs could extend the lives of thousands of patients with coronary heart disease, say researchers at The University of Nottingham.
The study, published in the latest British Medical Journal, found that combinations of cholesterol lowering drugs (statins), aspirin and beta-blockers, which lower blood pressure, improve survival rates in high-risk patients with cardiovascular disease.
However, despite proposals in the past that these drugs, combined into a ‘polypill’ with folic acid, should be given to all patients over the age of 55, the researchers found no evidence that this would be beneficial.
This is the first large-scale, long-term trial to look at the effect of different combinations of drugs to prevent deaths of patients with heart disease.
The study, led by Professor Julia Hippisley-Cox in the University’s Centre for Population Sciences, involved more than 13,000 patients who were diagnosed with ischaemic heart disease between 1996 and 2003.
The combination of statins, aspirin and beta-blockers appeared to improve survival rates most effectively — by 83 per cent. Adding another type of blood pressure lowering drug (an angiotensin converting enzyme (ACE) inhibitor) offered no extra benefit. At 19 per cent, beta-blockers alone were the least successful. ACE inhibitors offered just a 20 per cent reduction in risk.
The data came from the QRESEARCH database, run by The University of Nottingham in collaboration with the IT software provider EMIS. QRESEARCH automatically collects real-time data from 500 GP practices (representing around eight million patients) throughout the UK. The system anonymises and uploads practices’ clinical data to a central database.
Prof Julia Hippisley-Cox | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...