Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HIV Treatment Not Affected by Hormonal Birth Control

04.05.2005


Estrogen and progesterone hormones in birth control do not influence the effectiveness of highly active antiretroviral therapy (HAART), which is used to treat HIV infection, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions. The study is published in the May 1, 2005, issue of the American Journal of Epidemiology.



"Since the introduction of HAART in 1996, many studies have proven the effectiveness of these regimens in reducing mortality and HIV-associated morbidity. However, not all patients respond equally well and determining the factors that could affect response is an important area of research. Our research group set out to investigate whether hormonal contraception influenced response to HAART,” said Stephen J. Gange, PhD, corresponding author of the study and an associate professor in the Bloomberg School of Public Health’s Department of Epidemiology.

Data from the Women’s Interagency HIV Study (WIHS), the largest, ongoing study of HIV-infected and high-risk HIV-negative women in the United States, were examined. The study authors matched hormonal contraceptive users with nonusers, according to age, race/ethnicity, pre-HAART CD4+ T-lymphocyte counts and viral load. They investigated whether there were any effects on the two main markers of HIV disease progression, which are CD4 cell count and viral load. The researchers did not find an association between hormonal contraceptive use and changes in CD4+ cell count or time to viral load suppression after initiation of HAART. There was also no relationship between those outcomes and the duration of hormonal contraception use before HAART initiation.


The study results also reinforce the strong effects of HAART on HIV disease progression. The researchers found that women who used HAART continuously were almost 3 times more likely to experience a CD4+ cell-count increase of 50 cells/mm3, over 3.5 times more likely to achieve a CD4+ cell-count increase of 100 cells/mm3 and approximately 2.7 times more likely to achieve an undetectable viral load than nonusers.

“From a public health perspective, our findings alleviate concerns regarding suspected negative effects of hormonal contraceptive use on the response to HAART. However, sexually active HIV-infected women who wish to use hormonal contraceptives to prevent pregnancy should also continue using condoms to fight the spread of HIV,” said Dr. Gange.

The study authors recommend that follow-up data be collected after a greater number of years, in order to assess the effects of long-term exposure to hormonal contraceptives.

The study was supported by the National Institute of Allergy and Infectious Diseases, with supplemental funding from the National Cancer Institute, the National Institute of Child Health & Human Development and the National Institute on Drug Abuse.

Additional co-authors of the study were Jaclyn H. Chu, Kathryn Anastos, Howard Minkoff, Helen Cejtin, Melanie Bacon, Alexandra Levine and Ruth M. Greenblatt.

Public Affairs media contacts for the Johns Hopkins Bloomberg School of Public Health: Kenna Lowe or Tim Parsons at 410-955-6878 or paffairs@jhsph.edu.

Kenna L. Lowe | EurekAlert!
Further information:
http://www.jhsph.edu

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

Decoding cement's shape promises greener concrete

08.12.2016 | Materials Sciences

Will Earth still exist 5 billion years from now?

08.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>