Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vascular structure and function improve with diet and exercise

02.05.2005


American Heart Association meeting report:



Some structural and functional measures of cardiovascular disease risk may improve by the eighth week of a diet and exercise regimen, according to a study presented today at the American Heart Association’s Sixth Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology.

"Our lifestyle management program appears to improve the health of the vasculature, so it might lower the risk of high blood pressure, diabetes, heart attacks and stroke," said presenter and lead author Kunihiko Aizawa, M.Sc., a Ph.D. candidate at the University of Western Ontario in London, Ontario, Canada. "We found that there probably are some things that happen in even eight weeks."


Researchers studied the combined effects of personalized physical exercise and Mediterranean-style diet plans in volunteers with pre-clinical risk factors for cardiovascular disease. The study reported preliminary data from the larger randomized Staged Nutrition and Activity Counseling (SNAC) trial.

A Mediterranean-style diet has impressive cardio-protective effects, according to a 2001 American Heart Association scientific advisory. The diet is high in fruits, vegetables, bread, other forms of cereals, potatoes, beans, nuts and seeds with olive oil as an important fat source, and low to moderate amounts of dairy, fish and poultry.

"There have been studies looking at diet and exercise to prevent or treat cardiovascular disease," said primary investigator Robert J. Petrella, M.D., Ph.D., associate professor in the Schulich School of Medicine at the University of Western Ontario. "The difference here is that the calories and composition of the diet and physical activity prescribed were matched to fitness level in an individually tailored fashion and delivered in a family practice setting as opposed to a hospital or laboratory."

The randomized, single-blind trial of SNAC intervention versus usual care lifestyle counseling included 38 patients with high-normal blood pressure (systolic greater than 130 mmHg to 139 mmHg, diastolic greater than 85 mmHg to 89 mmHg) or pre-diabetes indicated by impaired fasting glucose or impaired glucose tolerance. The average age of patients was 53.3 years.

Researchers found that the 22 female and 16 male participants lost weight and improved their exercise capacity on the program. Treadmill tests were used to measure exercise capacity (VO2 max, the maximal volume of oxygen exchanged during exercise) at the beginning and end of the eight-week period. Average VO2 max increased from 32.1 milliliters per minute per kilogram (mL/min/kg) to 35.3 mL/min/kg. Average body weight decreased from 92.5 kg to 90.9 kg (203.5 pounds to 200 pounds).

"We were surprised that we saw such a weight reduction with the Mediterranean diet," Petrella said. "It was not a weight reduction program."

Blood pressure did not change significantly. Ultrasound measurements of the heart and blood vessels at rest were performed as well. Left ventricular diastolic filling (LVDF) measurements indicate the efficiency of the heart to relax. Left ventricular mass is a measure of end organ damage often following the onset of LVDF abnormalities.

The brachial (arm) and carotid (neck) arteries were tested for intima-media thickness and arterial distensibility. Both reflect the health of the blood vessels. The thicker and less distensible (elastic) the arteries are, the greater the load on the heart. This often results from changes in blood pressure, blood glucose or cholesterol disorders such as dyslipidemia.

Carotid artery distensibility was the only structural factor that significantly improved. It rose about 16 percent. Petrella said that the other factors may improve as patients are followed for one year.

One in three American adults has high blood pressure and two-thirds to three-fourths of people with diabetes mellitus die of some form of heart or blood vessel disease, according to the American Heart Association.

"For both of these groups, their lifetime risk of developing hypertension is high," Petrella said. "Anything we can do to reduce that is important."

Carole Bullock | EurekAlert!
Further information:
http://www.heart.org

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>