Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nano-particle research will benefit inhaler-users

02.05.2005


Patients suffering from asthma and diabetes could benefit



Patients suffering from conditions as diverse as asthma and diabetes could benefit from research at Cardiff University to improve the effectiveness of drugs taken through spray inhalers. Scientists in the Welsh School of Pharmacy are working on new nano-particle drug formulations for inhalers, and enhancers to improve the effectiveness of proteins, such as insulin, delivered to the lung.

"Drugs delivered through inhalers are usually either in a suspension (as particles dispersed in liquid), or in a solution (when the drug is dissolved in the liquid)," explained Dr James Birchall. "However, there are problems with both methods - a suspension can lead to sediment in the inhaler and less of the drug reaching the target area of the lung, while solutions present problems in dissolving the drug in the inhaler propellant liquid and can make the drug itself less stable."


The Cardiff team’s approach is to prepare the drug in nano-particle form – ensuring the correct dosage reaches the lung and the drug retains its stability, and providing the possibility of slowing the release of the drug in the lung for longer therapeutic effect.

This could lead to the possibility of more drugs being administered effectively by inhaler, rather than by tablet or injection.

Meanwhile, the team is also developing a process which uses a naturally occurring substance to enhance the absorption of insulin. Initial studies suggest insulin is absorbed three to four times more effectively by this process.

Now Dr Birchall and his colleague Dr Glyn Taylor of The Pulmonary Research Group aim to combine the two innovations to prolong and maximise the absorption effect.

"These two technologies could make a huge improvement in the effectiveness of spray inhalers for users suffering from a wide range of illnesses and conditions," said Dr Birchall.

Dr James Birchall | EurekAlert!
Further information:
http://www.cardiff.ac.uk

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>