Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Findings about anti-cancer agent could make it more effective

20.04.2005


New research has revealed the power behind an anti-tumor agent being studied in the laboratory. The findings, by scientists at Wake Forest University School of Medicine and the National Cancer Institute, could lead to more effective treatment strategies for cancer.



"Our new understanding of how this agent works could help us combine treatments to reach multiple targets," said William Gmeiner, Ph.D., professor of cancer biology at Wake Forest’s School of Medicine, which is part of Wake Forest University Baptist Medical Center.

Gmeiner is working under a grant from the National Cancer Institute (NCI) to investigate the agent’s potential for treating human cancer. His most recent findings reveal how the compound – called FdUMP[10] – works to damage DNA, the genetic "code" found in all cells.


The results were reported in Anaheim, Calif., today at the American Association for Cancer Research’s 96th Annual Meeting and will be published June 1 in Cancer Research.

Eleven years ago, Gmeiner set out to develop a compound that would be more effective and have fewer side effects than fluorouracil, one of the most common chemotherapy drugs for prostate cancer. Laboratory studies show that FdUMP[10] is 300 to 400 times more effective than fluorouracil at killing cancer cells and less damaging to normal cells. In addition to potential for treating prostate cancer, the compound has also proven effective for leukemia and colon cancer cells.

"Now, we have more information about how it’s actually killing cancer cells," said Gmeiner. "We knew that it damaged DNA but did not know the mechanism. Our latest research helped us learn what target we’re hitting."

Gmeiner designed the agent to inhibit an enzyme (thymidylate synthase) that plays a major role in the rapid growth and division of cancer cells. But his recent research shows that the agent also acts on another enzyme (topoisomerase) that helps cancer cells replicate.

"Inhibiting topoisomerase causes DNA strands to break, which is an important mechanism that leads to cell death," said Gmeiner.

Knowing more about how the agent works means that doctors could combine it with other drugs to reach multiple treatment targets. For example, FdUMP[10] could possibly be used in combination with drugs that employ other mechanisms to kill cells.

"We may be able to combine it with other treatments for greater effectiveness," said Gmeiner. "There are likely novel combinations that we wouldn’t have envisioned before this study."

Knowing more how the compound works would also allow scientists to monitor its effectiveness during treatment. Gmeiner said that if the compound continues to show promise in the laboratory, it could be tested in humans within a few years. The compound is licensed to AVI, a biopharmaceutical company.

Gmeiner’s co-researchers are Zhi-Yong Liao¬, Ph.D., Olivier Sordet, Ph.D., Hong-Liang Zhang, Ph.D., Glenda Kohlhagen, Ph.D., Smitha Antony, Ph.D., and Yves Pommier, M.D., Ph.D., all with the National Cancer Institute at the time of the research.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>