An investigational drug is producing powerful responses in patients resistant to Gleevec, the targeted therapy that helps most people diagnosed with chronic myeloid leukemia (CML), an international research team headed by investigators at The University of Texas M. D. Anderson Cancer Center is reporting.
The drug, AMN107, is showing an increasingly strong benefit as doses are being steadily raised, say the researchers, who presented their latest analysis at the annual meeting of the American Association for Cancer Research.
In an ongoing study that has enrolled more than 100 patients, over 90 percent of those with the earlier stage "chronic" phase of CML have had a hematologic response, meaning their blood counts have returned to normal, says Francis Giles, M.D., a professor of medicine in the Department of Leukemia at M. D. Anderson. Additionally, more than 70 percent of patients with the advanced "accelerated" and terminal "blast" stages of the disease have similarly benefited, and the number of complete molecular remissions in patients also is steadily increasing, he says.
Nancy Jensen | EurekAlert!
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