Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New approach to cancer treatment shown to be highly effective

19.04.2005


Attacking novel S1P target eliminates cancerous tumors in some cases



An antibody developed by San Diego-based Lpath Therapeutics, Inc. could someday treat many of the deadliest solid and liquid tumors. This unique monoclonal antibody, called SphingomabTM, was tested in several animal models of human cancer and was shown to significantly retard cancer growth on a consistent basis; in some cases, it eliminated the tumor altogether.

According to Roger Sabbadini, Founder and Chief Scientific Officer of Lpath Therapeutics, the company has developed a monoclonal antibody against sphingosine-1-phosphate (S1P) and has validated S1P as a therapeutic target for cancer. Lpath is now preparing to seek FDA approval for human trials.


The results of two studies supporting this novel approach to cancer therapy were released at the 96th Annual Meeting of the American Association for Cancer Research in Anaheim, California on April 18. One of the studies was presented by Gordon Mills, M.D., Ph.D., of The University of Texas M. D. Anderson Cancer Center. Dr. Mills has pioneered the study of the important role that lysolipids (like S1P) play in the growth and metastasis of cancer cells.

According to Dr. Mills, the most deadly, multi-resistant cancers--including lung, breast, melanoma, and ovarian cancers--responded well to the SphingomabTM approach of targeting S1P. The SphingomabTM treatment not only blocked the effects of S1P on the cancer cells themselves, but also prevented tumor angiogenesis, which is the formation of new blood vessels that feed the growing tumor.

Lpath Therapeutics believes that interfering with sphingolipid function can result in clinically relevant therapeutic outcomes. Sphingolipids are structural and multifunctional lipid mediators largely involved in signaling activities required for normal cellular function. However, sphingolipids can become dysfunctional and thereby contribute directly to the pathophysiology of cancer, inflammation, and cardiovascular diseases.

Lpath Therapeutics, Inc. was founded in 1998 at San Diego State University based on the work of Dr. Sabbadini in the area of sphingolipid research. Lpath initially focused on the role of sphingolipids in cardiovascular disease and later expanded its research around sphingolipids to treat a broad range of diseases, including cancer.

Dr. Roger Sabbadini | EurekAlert!
Further information:
http://www.Lpath.com

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>