Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue engineering experts discuss orthopaedics applications

11.04.2005


A future in which laboratory-grown organs and stimulated growth of muscle, bones and nerves could play a major role in treating medical conditions was revealed at a recent Tissue Engineering Symposium at Wake Forest University Baptist Medical Center.

The symposium, sponsored by Wake Forest Baptist and the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, was part of the society’s annual conference. Tissue engineering experts from Wake Forest Baptist, Children’s Hospital of Pittsburgh, Carnegie Mellon University, the University of Texas at Austin, as well as Italy and Japan, discussed their latest work.

Tissue engineering, a term that was coined in 1986, describes the science of replacing, repairing or regenerating organs or tissue. The term is often used interchangeably with regenerative medicine.



In the field of orthopaedics, researchers described using growth factors to regenerate bone, using new technologies to enhance the healing of ligaments, efforts to produce tissue-engineered cartilage, and the possibility of use stem cells derived from muscle to improve bone healing. These advances could provide better treatments for sports injuries, cleft palate and osteoporosis, the researchers said.

"The potential in orthopaedics is not only to manage devastating congenital or traumatic problems but also to prevent or slow degenerative processes in order to maintain the activity and function of our aging population," said Gary G. Poehling, M.D., professor and chairman of othopaedics at Wake Forest Baptist.

Anthony Atala M.D., director of the Wake Forest Institute of Regenerative Medicine, said that laboratory-grown organs may one day help alleviate the shortage of donated organs for transplantation. Atala has developed bioengineered urethras, the tube through which urine is excreted from the bladder, that have been successfully implanted in humans. He has also created blood vessels, muscle, bladders, wombs, and vaginas that have been successfully tested in large animals and are close to being ready to test in humans.

Atala’s team is working to use patients’ own cells to grow more than 20 different tissue types. They harvest cells from humans and apply growth factors, to cause the cells to multiply outside the body. It can take years to develop and perfect these growth factors, which cause a group of cells about one centimeter in size to multiply to fill a football field in about 60 days. The cells are "seeded" on a model, or scaffold, where they continue to grow. The next step is implanting the model in the body, where the scaffold eventually degrades as the new organ or tissue integrates with the body.

In addition to engineering tissues and organs, Atala and his team are also working to identify new sources of stem cells. Because these cells are unspecialized, they can acquire the structure and features of other cell types, and some researchers believe they could be used to replace defective insulin-producing cells in the pancreas, as well as to treat Alzheimer’s, liver, heart, muscular and vascular diseases.

Robert Nerem, Ph.D., director of the Parker H. Petit Institute for Bioengineering and Bioscience at the Georgia Institute of Technology predicted that one day tissue engineering and regenerative medicine will result in a revolution in the medical implant industry.

But Nerem and others who work in this emerging field said that while the area is full of promise, there are still many challenges to face before new therapies will be widely available.

"These technologies are expensive and for some of them, distribution is a challenge," said Atala.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>