Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue engineering experts discuss orthopaedics applications

11.04.2005


A future in which laboratory-grown organs and stimulated growth of muscle, bones and nerves could play a major role in treating medical conditions was revealed at a recent Tissue Engineering Symposium at Wake Forest University Baptist Medical Center.

The symposium, sponsored by Wake Forest Baptist and the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, was part of the society’s annual conference. Tissue engineering experts from Wake Forest Baptist, Children’s Hospital of Pittsburgh, Carnegie Mellon University, the University of Texas at Austin, as well as Italy and Japan, discussed their latest work.

Tissue engineering, a term that was coined in 1986, describes the science of replacing, repairing or regenerating organs or tissue. The term is often used interchangeably with regenerative medicine.



In the field of orthopaedics, researchers described using growth factors to regenerate bone, using new technologies to enhance the healing of ligaments, efforts to produce tissue-engineered cartilage, and the possibility of use stem cells derived from muscle to improve bone healing. These advances could provide better treatments for sports injuries, cleft palate and osteoporosis, the researchers said.

"The potential in orthopaedics is not only to manage devastating congenital or traumatic problems but also to prevent or slow degenerative processes in order to maintain the activity and function of our aging population," said Gary G. Poehling, M.D., professor and chairman of othopaedics at Wake Forest Baptist.

Anthony Atala M.D., director of the Wake Forest Institute of Regenerative Medicine, said that laboratory-grown organs may one day help alleviate the shortage of donated organs for transplantation. Atala has developed bioengineered urethras, the tube through which urine is excreted from the bladder, that have been successfully implanted in humans. He has also created blood vessels, muscle, bladders, wombs, and vaginas that have been successfully tested in large animals and are close to being ready to test in humans.

Atala’s team is working to use patients’ own cells to grow more than 20 different tissue types. They harvest cells from humans and apply growth factors, to cause the cells to multiply outside the body. It can take years to develop and perfect these growth factors, which cause a group of cells about one centimeter in size to multiply to fill a football field in about 60 days. The cells are "seeded" on a model, or scaffold, where they continue to grow. The next step is implanting the model in the body, where the scaffold eventually degrades as the new organ or tissue integrates with the body.

In addition to engineering tissues and organs, Atala and his team are also working to identify new sources of stem cells. Because these cells are unspecialized, they can acquire the structure and features of other cell types, and some researchers believe they could be used to replace defective insulin-producing cells in the pancreas, as well as to treat Alzheimer’s, liver, heart, muscular and vascular diseases.

Robert Nerem, Ph.D., director of the Parker H. Petit Institute for Bioengineering and Bioscience at the Georgia Institute of Technology predicted that one day tissue engineering and regenerative medicine will result in a revolution in the medical implant industry.

But Nerem and others who work in this emerging field said that while the area is full of promise, there are still many challenges to face before new therapies will be widely available.

"These technologies are expensive and for some of them, distribution is a challenge," said Atala.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

NASA Protects its super heroes from space weather

17.08.2017 | Physics and Astronomy

Spray-on electric rainbows: Making safer electrochromic inks

17.08.2017 | Materials Sciences

Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

17.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>