Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A possible new phase for rheumatoid arthritis treatment

07.04.2005


The pathology of rheumatoid arthritis within the first few months after symptom onset is distinct from that of the early phases of other inflammatory joint diseases and also of established rheumatoid arthritis. New research published today in Arthritis Research & Therapy found that very early rheumatoid arthritis is characterised by a distinct profile of T cell, macrophage and stromal cell related cytokines in synovial fluid.



This finding of a distinct phase of rheumatoid arthritis, immediately after the onset of clinical symptoms, provides a new rationale for the very early treatment of rheumatoid arthritis - before the disease develops into a long-term condition.

The synovium, the connective tissue membrane that lines the joints, is the primary site of pathology in rheumatoid arthritis. Although the processes that maintain long-term inflammation of the synovium in rheumatoid arthritis have been well studied, those initiating the inflammation have not, and very few groups have studied the pathology of rheumatoid arthritis within the first few weeks after the onset of symptoms.


Karim Raza and colleagues, from the University of Birmingham, U.K., investigated the processes occurring in the joints of patients within 3 months of the onset of clinical symptoms. They assessed a panel of T cell, macrophage and stromal cell related cytokines and chemokines in synovial fluid samples from inflamed joints of these patients with very early arthritis. Patients who eventually developed persistent rheumatoid arthritis had a cytokine profile that was different from that seen in patients in the early phases of other arthritic diseases, and also from that in longstanding rheumatoid arthritis - suggesting a distinct pathological process during the early phase of rheumatoid arthritis.

Rheumatoid arthritis is a common, serious and disabling autoimmune disease in which inflammation of the joint lining (or synovium) results when the body’s tissues are mistakenly attacked by the immune system. Approximately eight million people are affected by rheumatoid arthritis in the UK.

Raza and colleagues speculate that the cytokines present in very early rheumatoid arthritis may be involved in the development of the microenvironment required for chronic disease. The authors propose that there is now a strong biological rationale for testing the effects of potent anti-inflammatory therapies during the first few months of clinically apparent disease. "The pathologically distinct nature of the very early phase of clinically apparent rheumatoid arthritis suggests that this phase may represent a therapeutic window", said Dr Karim Raza.

Juliette Savin | EurekAlert!
Further information:
http://www.biomedcentral.com

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>