Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

ALLHAT findings are ’color blind’ in showing diuretics work better for high blood pressure

06.04.2005


Three University of Texas School of Public Health at Houston faculty members are co-authors of an article in the April 6 issue of The Journal of the American Medical Association. The article reports study results suggesting older, cheaper diuretics remain the drug of choice for both black and non-black patients in treating high blood pressure and reducing risk of heart disease.



The analysis by race of the "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial" (ALLHAT), confirms earlier findings that diuretics rather than newer, more expensive drugs such as ACE inhibitors, calcium channel blockers, or beta blockers should be preferred as a first therapy for most patients.

The multi-center ALLHAT study is conducted under a National Institutes of Health contract with The University of Texas Health Science Center at Houston. Barry R. Davis, M.D., Ph.D., professor of biostatistics in the UT School of Public Health is the Principal Investigator and a co-author of the JAMA article.


"There was question whether the diuretics’ success with hypertension applied by race because black patients have less success than non-black patients with the ACE inhibitors," said Davis, who also is director of the Coordinating Center for Clinical Trials at the UT School of Public Health. "However the results showed diuretics were as good or better than the newer drugs regardless of race."

The study concludes that diuretics are similar to or superior to newer drugs in lowering blood pressure, in tolerability and in preventing the major complications from high blood pressure. Across both racial subgroups, there was substantially higher risk of heart failure--37 percent--among participants taking calcium channel blockers compared with those on diuretics. When compared to ACE inhibitors, diuretics were more effective in preventing cardiovascular disease, especially heart failure, for all participants and significantly more effective in reducing high blood pressure and preventing stroke in blacks.

"These findings confirm ALLHAT’s original conclusion that diuretics should be the preferred initial therapy for high blood pressure," Davis said.

Melanie Hillis | EurekAlert!
Further information:
http://www.uth.tmc.edu

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>