Chagas disease, which is transmitted to humans by a blood-sucking insect known as an Assassin bug, is the most devastating parasitic infection in Central and South America and Mexico. The protozoan parasite that causes the disease, Trypanosoma cruzi, infects 16 to 18 million people, causing severe chronic illness and tens of thousands of deaths per year.
Until now, there has been no effective treatment for the long-term, chronic form of Chagas disease, which kills up to one-third of those infected, usually by heart failure. However, two Howard Hughes Medical Institute (HHMI) international research scholars have now found that in mice, a compound called TAK-187 is significantly more effective than the current standard of care - the drug benznidazole - in preventing T. cruzi-induced cardiac damage. Julio Urbina from the Venezuelan Institute for Scientific Research, Miguel Angel Basombrio from the National University of Salta, and colleagues report their findings in an early online publication of the April issue of the journal Antimicrobial Agents and Chemotherapy.
“Only one percent of the new drugs introduced to the market in the last 25 years were developed to treat tropical diseases, despite the enormous unmet need for such compounds.”
Jennifer Donovan | EurekAlert!
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Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
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