Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

More evidence of cannabis-induced psychosis

01.04.2005


Cannabis-based medicines given in a highly-controlled clinical environment unexpectedly lead to strong psychotic effects



Volunteers taking cannabis-based therapeutic drugs as part of a controlled trial, which had been approved by an ethics board as safe for the subjects, experienced psychotic effects just as strong as if they had smoked cannabis. These findings, highly unexpected in such a controlled environment, are published today in the peer-reviewed, Open Access journal BMC Psychiatry.

Dr Bernard Favrat and colleagues, from the Institut Universitaire de Medecine Legale in Switzerland, were conducting a clinical trial into the effects of orally administered delta-9-tetrahydrocannibol (THC), the active ingredient in cannabis, when two of their male subjects experienced impaired psychomotor functions and severe anxiety typical of cannabis-induced psychosis.


When smoking cannabis, the effects of THC on psychomotor functions usually start once the concentration in the blood has reached 10ng/ml plasma. The trial should have been safe as the subjects were given low doses of THC and had much lower concentrations in their blood. However the two male subjects experienced their reactions with blood concentrations of 4.7ng/ml and 6.2 ng/ml, respectively.

Favrat and colleagues found that both subjects reported severe anxiety and impaired psychomotor functions. Other effects included transient symptoms of derealisation and depersonalisation, and paranoid delusions. They were described by one subject as worse than those experienced after smoking cannabis. One subject was given dronabinol, a synthetic THC that has been in medical use in the USA since 1985. The other subject was asked to drink a decoction of natural THC. The authors hypothesise that the effect may have been because the THC had been ingested, rather than inhaled; digesting THC may produce potent THC metabolites, which induce psychotic effects.

Research into designing THC-based medications has boomed in the last few years, due to the many therapeutic effects of THC. These drugs could be used to alleviate muscle spasticity in multiple sclerosis patients, restore appetite in AIDS patients and alleviate pain and nausea in cancer patients undergoing chemotherapy. Such research has to be approved to ensure that it is treating patients ethically and safely. Dr Favrat’s research had been approved, which makes the findings even more unexpected.

Favrat and colleagues’ report adds to the body of evidence that cannabis might be more harmful than previously thought. In the UK, cannabis was downgraded to class C early last year, but government officials have called for a review of the decision following a series of studies revealing that cannabis dramatically increases the risk of developing mental illnesses.

Juliette Savin | EurekAlert!
Further information:
http://www.biomedcentral.com

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>