Benefit may be confined primarily to those with certain genetic variants, more research needed
The association between regular aspirin use and a reduced risk of precancerous colon polyps may be strongest in those with particular genetic variants. In the March 16 Journal of the National Cancer Institute, researchers report that aspirin use appears to reduce the incidence of colon polyps more strongly in women with alternative forms of a gene involved in the metabolism of aspirin than in those with the most common form of the gene. The report – from researchers at Massachusetts General Hospital (MGH), Brigham and Womens Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) – analyzes data from the Nurses Health Study.
"Several studies by our group and others have suggested that aspirin may help prevent colon polyps, but since aspirin therapy also has risks, it would be helpful to identify those who are most likely to benefit," says Andrew T. Chan, MD, MPH, of the MGH Gastrointestinal Unit, the papers lead author. "We decided to look at the gene for an enzyme that metabolizes aspirin and is known to have variant forms that slow down that process."
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21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
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The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
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21.04.2017 | Physics and Astronomy