Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

DES Exposure May Impair Later Function of the Uterus

11.03.2005


A new study by Tulane University researchers, published in the March edition of Molecular Endocrinology, provides insight into one of the ways diethylstilbesterol (DES) may alter the development of the uterus.



DES, a synthetic estrogen, was prescribed to prevent miscarriage in many women who were pregnant between 1941 until 1971. In 1971, DES was banned in the United States due to concerns about the occurrence of cancer and infertility in the daughters of women who took it.

“Several millions of pregnant women were treated with DES and we have continued to study and model the disease since it provides unique insights into what estrogenic chemicals may do to the developing fetus,” says study co-author John McLachlan, director of the Center for Bioenvironmental Research at Tulane and Xavier Universities. “There are other chemicals in our environment -- the results of industrial, agriculture and chemical processing -- that, while their estrogenic affect is weaker, may affect developing embryos in the same way. We need models to understand the cellular and genetic mechanisms by which environmental chemicals work. This study is a step in that direction.”


Exposing a newborn mouse to DES may interfere with the proper development of the uterus, say Tulane University researchers. In this study, the scientists provide evidence that exposure to DES early in life can change the way genes are expressed in the uterus of mice long after the chemical treatment is stopped. This work is on the cutting edge of an area of scientific research called genetic imprinting, say the researchers.

“The results of this study and those from other labs suggest that some diseases seen in adults may have started with exposure to chemicals while in the womb,” McLachlan says. “This is a whole new kind of birth defect.”

| newswise
Further information:
http://www.tulane.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>