Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pioneering PET/CT research widens applications of imaging for diabetic foot

09.03.2005


Pioneering research with combined positron emission tomography (PET) and computed tomography (CT) scans provides accurate detection and localization of foot infection in diabetic patients, according to an article in the March issue of the Journal of Nuclear Medicine. PET/CT scans could potentially offer a single-step, noninvasive technique for the diagnosis of infection, said Society of Nuclear Medicine member Zohar Keidar, M.D., Ph.D., the article’s lead author.



Keidar explained that foot infection is one of the most severe complications of diabetes. Diabetes can lead to decreased circulation in one’s extremities. This poor circulation--and the reduced ability to fight off minor infections--put diabetics at risk for development of chronic infection involving bone and soft tissues. "Early detection of infection is crucial and may prevent amputation," said Keidar, explaining that antibiotic therapy can cure these infections if administered in time.

Keidar and his colleagues at Rambam Medical Center in Haifa, Israel, used PET/CT, the novel technology that combines two imaging modalities in one device, in their study of foot infection. By using labeled glucose (radiotracer 18F-FDG), Israeli physicians demonstrated the presence of infection with PET imaging. CT scans showed the localization of the infection site detected by PET as well as structural changes in bone and soft tissues. "This combined imaging approach in a single session using a single device leads to better localization of the infection process and facilitates the diagnosis," noted the lead author of "The Diabetic Foot: Initial Experience With 18F-FDG PET/CT." PET/CT technology, which is being used currently for cancer evaluation, may be applied potentially to the investigation of infection during evaluation of prolonged fever, suspected infected vascular graft or limb prosthesis, he added.


The group’s preliminary results have been "enthusiastically welcomed" by nuclear medicine professionals and referring physicians, especially orthopedic and vascular surgeons, said Keidar, who is with Rambam Medical Center’s department of nuclear medicine and Technion–Israel Institute of Technology’s school of medicine, both in Haifa, Israel. He believes that these findings will encourage additional investigations on the role of PET/CT in infection and inflammation in larger patient populations.

The authors of "The Diabetic Foot: Initial Experience With 18F-FDG PET/CT" are Zohar Keidar, M.D., Ph.D., Rambam Medical Center’s department of nuclear medicine and Technion–Israel Institute of Technology’s school of medicine, both in Haifa, Israel; Daniela Militianu, M.D., Rambam Medical Center’s department of diagnostic radiology, Haifa, Israel; Eyal Melamed, M.D., Rambam Medical Center’s department of orthopedics, Haifa, Israel; SNM member Rachel Bar-Shalom, M.D., Rambam Medical Center’s department of nuclear medicine, Haifa, Israel; and SNM member Ora Israel, M.D., Rambam Medical Center’s department of nuclear medicine and Technion–Israel Institute of Technology’s school of medicine, both in Haifa, Israel.

Maryann Verrillo | EurekAlert!
Further information:
http://www.snm.org

More articles from Health and Medicine:

nachricht Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>